Betriu C, Gomez M, Sanchez A, Cruceyra A, Romero J, Picazo J J
Servicio de Microbiología Clínica, Hospital Universitario San Carlos, Madrid, Spain.
Antimicrob Agents Chemother. 1994 Sep;38(9):2183-6. doi: 10.1128/AAC.38.9.2183.
The aim of this study was to determine the susceptibility patterns of 100 group B streptococcal strains isolated in our hospital and to ascertain tolerance to penicillin by determining quantitative killing curves. We found two strains with intermediate susceptibility to penicillin and eight strains to ampicillin. Seventeen isolates were tolerant to penicillin, with bacterial counts decreasing 2 to 3 log during the first 8 h but still above 10(2) CFU/ml after 24 h. The kinetic study shows that penicillin tolerance is not rare among group B streptococci isolated in our hospital.
本研究的目的是确定我院分离出的100株B族链球菌菌株的药敏模式，并通过测定定量杀菌曲线来确定对青霉素的耐受性。我们发现有两株对青霉素中度敏感，八株对氨苄西林中度敏感。17株分离菌对青霉素耐受，在前8小时细菌数量减少2至3个对数，但24小时后仍高于10²CFU/ml。动力学研究表明，在我院分离出的B族链球菌中，青霉素耐受性并不罕见。
