Lee M V, Ambrus J L, DeSouza J M, Lee R V
J Med. 1982;13(5-6):479-85.
Six patients with active P. falciparum malaria (two resistant to chloroquine therapy), one with treated and apparently cured P. falciparum malaria, one with active P. vivax malaria and two controls from the same geographic area of Amazonian Brazil were studied. All malaria patients had impaired red cell deformability. This was not correlated with drug resistance or number of parasitized cells. The hypothesis is presented that the presence of parasites in red blood cells and related metabolic effects produce decreased red cell deformability and may lead to microvascular perfusion deficiencies including cerebral malaria.
对6例患恶性疟原虫疟疾的患者（其中2例对氯喹治疗耐药）、1例曾接受治疗且明显已治愈的恶性疟原虫疟疾患者、1例患间日疟原虫疟疾的患者以及来自巴西亚马逊同一地理区域的2名对照者进行了研究。所有疟疾患者的红细胞变形能力均受损。这与耐药性或被寄生细胞的数量无关。有人提出这样的假说，即红细胞内寄生虫的存在及相关代谢效应会导致红细胞变形能力下降，并可能导致包括脑型疟疾在内的微血管灌注不足。
