Miller R R
Pharmacotherapy. 1981 Jul-Aug;1(1):21-7. doi: 10.1002/j.1875-9114.1981.tb03550.x.
Ibuprofen is a derivative of propionic acid that was originally marketed in the United States as an antirheumatic agent in 1974. In 1979, it was approved for use as an analgesic. Of the 18 published double-blind clinical trials reviewed, only 6 were well designed. These six studies provide strong evidence that ibuprofen is effective for dental pain due to tooth extractions, dysmenorrhea and episiotomy pain. Thus, ibuprofen appears to be an effective drug for mild to moderate pain. It is as effective or more effective than aspirin, codeine or propoxyphene. Recommended initial dosage is 300 mg every six hours, increasing as needed to 400 mg every four hours. Adverse effects are relatively minor and infrequent.
布洛芬是丙酸的衍生物，1974年最初在美国作为抗风湿药上市。1979年，它被批准用作镇痛药。在所审查的18项已发表的双盲临床试验中，只有6项设计良好。这六项研究提供了有力证据，表明布洛芬对拔牙引起的牙痛、痛经和会阴切开术疼痛有效。因此，布洛芬似乎是一种治疗轻至中度疼痛的有效药物。它与阿司匹林、可待因或丙氧芬一样有效或更有效。推荐初始剂量为每六小时300毫克，必要时可增加至每四小时400毫克。副作用相对较小且不常见。
