未能检测到自然存在的乙肝病毒脱氧核糖核酸聚合酶血清抑制剂。
Failure to detect naturally occurring serum inhibitors of hepatitis B virus deoxyribonucleic acid polymerase.
作者信息
Hess G, Arnold G, Dormeyer H H, Koesters W, Gahl G, Hoffmann H G, Schönborn H, Meyer zum Büschenfelde K H
出版信息
Infect Immun. 1980 Mar;27(3):793-7. doi: 10.1128/iai.27.3.793-797.1980.
Sera of patients with past or ongoing hepatitis -B virus infection were tested for the presence of inhibitors of hepatitis -B virus-specific deoxyribonucleic acid (DNA) polymerase activity. None of the sera tested, which included those from anti-hepatitis B surface- and anti-hepatitis B core antigen-positive hemophiliacs, anti-hepatitis Bc antigen-positive hepatitis B surface antigen carriers, patients with hepatitis B surface antigen-positive chronic active hepatitis, hepatitis B surface antigen-positive hemodialysis patients, tumor patients with minimal hepatitis, patients with acute type B, type A, and type non-A, non-B hepatitis and individuals with autoimmune phenomena, contained inhibitors of DNA polymerase activity. This implies that the DNA polymerase test is not affected when utilized to quantitate DNA-containing Dane particles. In addition, there is no evidence that inhibitors of DNA polymerase activity play some pathogenic role in the course of hepatitis B virus infection.
对曾感染或正在感染乙型肝炎病毒的患者血清进行检测，以确定是否存在乙型肝炎病毒特异性脱氧核糖核酸（DNA）聚合酶活性抑制剂。所检测的血清中均未发现DNA聚合酶活性抑制剂，这些血清包括来自抗乙型肝炎表面抗原和抗乙型肝炎核心抗原阳性的血友病患者、抗乙型肝炎核心抗原阳性的乙型肝炎表面抗原携带者、乙型肝炎表面抗原阳性的慢性活动性肝炎患者、乙型肝炎表面抗原阳性的血液透析患者、轻度肝炎的肿瘤患者、急性乙型、甲型和非甲非乙型肝炎患者以及有自身免疫现象的个体。这表明，在用于定量含DNA的丹氏颗粒时，DNA聚合酶检测不受影响。此外，没有证据表明DNA聚合酶活性抑制剂在乙型肝炎病毒感染过程中发挥某种致病作用。
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