无症状乙肝表面抗原携带者中乙肝病毒特异性标志物的表达
Expression of hepatitis B virus-specific markers in asymptomatic hepatitis B surface antigen carriers.
作者信息
Arnold G H, Shih J W, Kaplan P M, Purcell R H, Gerin J L, Bueschenfelde K H
出版信息
Infect Immun. 1977 Sep;17(3):550-4. doi: 10.1128/iai.17.3.550-554.1977.
Abstract
A study was undertaken to assess the state of hepatitis B virus infection in a group of asymptomatic hepatitis B surface antigen (HBsAg) carriers. This study confirmed that the presence of hepatitis B e antigen (HBeAg) in serum was closely associated with serum HBsAg-specific deoxyribonucleic acid polymerase activity, hepatitis B core antigen (HBcAg) in serum and liver cell nuclei, and a histological picture of chronic hepatitis. No HBsAg-specific deoxyribonucleic acid polymerase activity or HBcAg was detected in highly concentrated anti-HBe-positive sera. In addition, liver biopsy specimens from carriers with anti-HBe were negative for HbcAg by immunofluorescence, and the liver histology was either normal or revealed only fatty changes. These data indicate that the anti-HBe-positive sera contained either no Dane particles or, if present, at least a 500-fold-lower concentration of Dane particles than that found in HBeAg-positive sera.
摘要
开展了一项研究，以评估一组无症状乙肝表面抗原（HBsAg）携带者的乙肝病毒感染状况。该研究证实，血清中乙肝e抗原（HBeAg）的存在与血清HBsAg特异性脱氧核糖核酸聚合酶活性、血清和肝细胞核中的乙肝核心抗原（HBcAg）以及慢性肝炎的组织学表现密切相关。在高浓度抗-HBe阳性血清中未检测到HBsAg特异性脱氧核糖核酸聚合酶活性或HBcAg。此外，抗-HBe携带者的肝活检标本经免疫荧光检测HbcAg为阴性，肝脏组织学要么正常，要么仅显示脂肪变性。这些数据表明，抗-HBe阳性血清中要么不含 Dane 颗粒，要么即便存在，其 Dane 颗粒浓度至少比 HBeAg 阳性血清中低500倍。
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