恰加斯病患者血浆中胰腺和胃肠激素及生长激素对口服和静脉注射葡萄糖与胰岛素低血糖的反应
Response of plasma pancreatic and gastrointestinal hormones and growth hormone to oral and intravenous glucose and insulin hypoglycaemia in Chagas's disease.
作者信息
Long R G, Albuquerque R H, Prata A, Barnes A J, Adrian T E, Christofides N D, Bloom S R
出版信息
Gut. 1980 Sep;21(9):772-7. doi: 10.1136/gut.21.9.772.
Abstract
Plasma hormonal responses to insulin hypoglycaemia and to oral and intravenous glucose were investigated in chagasic patients with severe bowel disease and compared with controls matched for age, sex, weight, and race. After intravenous insulin, plasma concentrations of pancreatic glucagon and pancreatic polypeptide (PP) were reduced in the patients with Chagas's disease. These subjects also showed a subnormal rise in plasma insulin after oral glucose. Other hormone responses did not differ significantly from those in the normal controls. These results are compatible with partial denervation of the pancreatic alpha, beta, and PP cells in patients with chronic gastrointestinal Chagas's disease.
摘要
对患有严重肠道疾病的恰加斯病患者，研究了其血浆激素对胰岛素低血糖以及口服和静脉注射葡萄糖的反应，并与年龄、性别、体重和种族相匹配的对照组进行比较。静脉注射胰岛素后，恰加斯病患者的血浆胰高血糖素和胰多肽（PP）浓度降低。这些受试者口服葡萄糖后血浆胰岛素的升高也低于正常水平。其他激素反应与正常对照组无显著差异。这些结果与慢性胃肠道恰加斯病患者的胰腺α、β和PP细胞部分去神经支配相符。
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