Uthemann H, Kotitschke R, Lissner R, Goerz G
Dtsch Med Wochenschr. 1980 Dec 5;105(49):1718-20. doi: 10.1055/s-2008-1070943.
Using several seromarkers for hepatitis B virus the frequency of previous hepatitis B in patients with porphyria cutanea tarda (PCT) as a possible manifestation factor was determined. As chronic hepatitis is frequently associated with an increase of factor VIII-associated antigen, this was included in the investigation. Results make it likely that 28 out of 60 investigated patients (47%) have had hepatitis. In 30% an increase of factor VIII-associated antigen was found. It can be assumed that hepatitis B virus infection as a manifestation factor may be of considerable importance in porphyria cutanea tarda when genetic disposition (uroporphyrinogen-decarboxylase deficiency) is present.
通过使用多种乙肝病毒血清标志物，确定了迟发性皮肤卟啉症（PCT）患者既往感染乙肝的频率，将其作为可能的表现因素。由于慢性肝炎常与Ⅷ因子相关抗原增加有关，因此该抗原也纳入了研究。结果显示，60例受调查患者中有28例（47%）可能曾感染过肝炎。30%的患者发现Ⅷ因子相关抗原增加。可以推测，当存在遗传易感性（尿卟啉原脱羧酶缺乏）时，乙肝病毒感染作为一种表现因素在迟发性皮肤卟啉症中可能具有相当重要的意义。
