Grimwood K, Johnson-Barrett J J, Taylor B
Br Med J (Clin Res Ed). 1981 Jan 10;282(6258):105-6. doi: 10.1136/bmj.282.6258.105.
A study was carried out to ascertain the most effective method of giving salbutamol. Seventeen children with severe asthma received active salbutamol (4 mg via a nebuliser, 400 micrograms as an inhalational powder, or a 4 mg tablet) together with complementary placebos on a double-blind, triple-dummy randomly allocated basis. The bronchodilatation effect was assessed by measuring the peak expiratory flow rate. The bronchodilatation effect was greatest when patients received nebulised salbutamol (p less than 0.05) but lasted longest when they received the tablet (p less than 0.0001); the onset of the effect was rapid with all forms of administration. These results indicate that nebulised salbutamol gives the best relief in severe asthma; in less severe cases, however, a regimen combining the inhalational powder and tablets is sufficient and more convenient.
开展了一项研究以确定给予沙丁胺醇的最有效方法。17名重度哮喘患儿在双盲、三模拟随机分配的基础上接受了活性沙丁胺醇（通过雾化器给予4毫克、吸入粉剂给予400微克或4毫克片剂）以及补充安慰剂。通过测量呼气峰值流速评估支气管扩张效果。当患者接受雾化沙丁胺醇时支气管扩张效果最佳（p<0.05），但当他们接受片剂时效果持续时间最长（p<0.0001）；所有给药形式的起效都很快。这些结果表明，雾化沙丁胺醇在重度哮喘中能提供最佳缓解效果；然而，在不太严重的病例中，吸入粉剂和片剂联合使用的方案就足够了且更方便。
