人胎儿肝脏和脐血淋巴细胞的游离免疫球蛋白轻链合成

Free immunoglobulin light chain synthesis by human foetal liver and cord blood lymphocytes.

作者信息

Hannam-Harris A C, Smith J L

出版信息

Immunology. 1981 Jul;43(3):417-23.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1555063/

Abstract

Immunoglobulin (Ig) synthesis by immature B lymphocytes from human foetal liver and cord blood has been investigated. Seven out of fifteen preparations of foetal liver cells and eight out of eleven cord bloods synthesized Ig detectable by biosynthetic labelling. All cultures of foetal lymphocytes with detectable Ig synthesis secreted free light chain. Two of these cases also synthesized free mu heavy chain. Cord blood lymphocyte synthesis patterns were variable ranging from free light chain as the only secreted Ig product to balanced synthesis of heavy and light chains. No cord blood cultures synthesized detectable free mu chains. Free Ig-light-chain synthesis appears to be associated with normal immature B lymphocytes and the results are discussed in relation to the B-cell differentiation pathway.

摘要

对来自人类胎儿肝脏和脐带血的未成熟B淋巴细胞的免疫球蛋白（Ig）合成进行了研究。15份胎儿肝细胞制剂中有7份以及11份脐带血中有8份通过生物合成标记可检测到Ig合成。所有可检测到Ig合成的胎儿淋巴细胞培养物均分泌游离轻链。其中两例还合成了游离μ重链。脐带血淋巴细胞的合成模式各不相同，从仅分泌游离轻链作为唯一的Ig产物到重链和轻链的平衡合成。没有脐带血培养物合成可检测到的游离μ链。游离Ig轻链的合成似乎与正常未成熟B淋巴细胞有关，并结合B细胞分化途径对结果进行了讨论。

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