Henderson R D, Woolfe C R
Can J Surg. 1978 Jul;21(4):352-4.
Gastroesophageal reflux is the commonest esophageal cause of chronic intermittent aspiration. The authors investigated 1000 consecutive patients with reflux with reference to their medical history, and by barium esophagography, esophageal manometry and pH studies. In patients with respiratory complications, chest roentgenography and pulmonary function tests were also performed. Of the total number, 279 patients aspirated either by coughing and choking during swallowing or as a result of night reflux; of these, 159 had associated respiratory symptoms, which included cough, voice change, recurrent respiratory infection, bronchiectasis and asthma. Of the patients with aspiration, 120 had surgical correction of reflux because conservative management failed. This form of reflux control improved the symptoms of cough and voice change and the condition of patients with recurrent infections or bronchiectasis, but alleviated the symptoms in only 8 of 28 asthmatic persons.
胃食管反流是慢性间歇性误吸最常见的食管病因。作者对连续1000例反流患者进行了病史调查，并通过食管钡餐造影、食管测压和pH值研究进行评估。对于有呼吸系统并发症的患者，还进行了胸部X线检查和肺功能测试。在总数中，279例患者在吞咽时因咳嗽和呛噎或因夜间反流而发生误吸；其中159例伴有呼吸道症状，包括咳嗽、声音改变、反复呼吸道感染、支气管扩张和哮喘。在有误吸的患者中，120例因保守治疗失败而接受了反流手术矫正。这种反流控制形式改善了咳嗽和声音改变的症状以及反复感染或支气管扩张患者的病情，但仅缓解了28例哮喘患者中8例的症状。
