用伴刀豆球蛋白A对小鼠脾细胞进行体外培养后，增强对单核细胞增生李斯特菌的免疫过继转移。
Enhanced adoptive transfer of immunity to Listeria monocytogenes after in vitro culture of murine spleen cells with concanavalin A.
作者信息
Barry R A, Hinrichs D J
出版信息
Infect Immun. 1982 Feb;35(2):560-5. doi: 10.1128/iai.35.2.560-565.1982.
Abstract
In vitro incubation of spleen cells with T-cell mitogens has been shown to augment cytotoxic and cytolytic T-cell function. The plant lectins Concanavalin A and phytohemagglutinin were employed in a similar fashion to investigate their abilities to enhance cell-mediated immunity to the microbial pathogen Listeria monocytogenes. Spleen cells from immune mice were incubated in vitro with Concanavalin A or phytohemagglutinin before passive transfer into normal recipients. Results indicated a 10- to 100-fold enhancement in the ability of these cells stimulated in vitro to transfer antilisterial resistance, as assayed by changes in 50% lethal dose values and enumeration of splenic bacterial proliferation.
摘要
已证明用T细胞有丝分裂原对脾细胞进行体外培养可增强细胞毒性和溶细胞性T细胞功能。以类似方式使用植物凝集素刀豆球蛋白A和植物血凝素，以研究它们增强针对微生物病原体单核细胞增生李斯特菌的细胞介导免疫的能力。将来自免疫小鼠的脾细胞在体外与刀豆球蛋白A或植物血凝素一起孵育，然后被动转移到正常受体中。结果表明，通过50%致死剂量值的变化和脾细菌增殖计数测定，体外刺激的这些细胞转移抗李斯特菌抗性的能力提高了10到100倍。
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