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血友病、类风湿性关节炎及其他风湿性疾病患者滑膜中的抗凝抗体。

Anticoagulant antibodies in the synovial membranes of patients suffering from haemophilia, rheumatoid arthritis and other rheumatic disorders.

作者信息

Rainsford S G, Aronstam A, Holborow E J, McLellan D S

出版信息

J Clin Pathol. 1982 Jun;35(6):673-80. doi: 10.1136/jcp.35.6.673.

DOI:10.1136/jcp.35.6.673
PMID:6806334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC497748/
Abstract

This study has identified IgG and IgM anticoagulant antibodies in the synovial membranes of patients suffering from haemophilia and rheumatoid arthritis (RA) but not in synovial tissues from normal subjects or in patients with other arthritides. In the majority of cases the antibody appeared to have the specificity of the lupus-like anticoagulant (LLA) seen in patients with systemic lupus erythematosus (SLE). The importance of these findings with regard to the treatment of certain cases of haemophilia and RA and the possible relation between the presence of these antibodies and viral infections is discussed.

摘要

本研究在血友病和类风湿性关节炎（RA）患者的滑膜中发现了IgG和IgM抗凝抗体，但在正常受试者的滑膜组织或其他关节炎患者中未发现。在大多数情况下，该抗体似乎具有系统性红斑狼疮（SLE）患者中所见的狼疮样抗凝剂（LLA）的特异性。本文讨论了这些发现对于某些血友病和RA病例治疗的重要性，以及这些抗体的存在与病毒感染之间的可能关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39da/497748/4b6645d480ff/jclinpath00499-0092-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39da/497748/4b6645d480ff/jclinpath00499-0092-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39da/497748/4b6645d480ff/jclinpath00499-0092-a.jpg

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Anticoagulant antibodies in the synovial membranes of patients suffering from haemophilia, rheumatoid arthritis and other rheumatic disorders.血友病、类风湿性关节炎及其他风湿性疾病患者滑膜中的抗凝抗体。
J Clin Pathol. 1982 Jun;35(6):673-80. doi: 10.1136/jcp.35.6.673.
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本文引用的文献

1
The latex fixation test. I. Application to the serologic diagnosis of rheumatoid arthritis.乳胶凝集试验。I. 在类风湿性关节炎血清学诊断中的应用。
Am J Med. 1956 Dec;21(6):888-92.
2
The treatment of patients who have factor-VIII antibodies.患有因子VIII抗体患者的治疗。
Br J Haematol. 1973 Jan;24(1):65-82. doi: 10.1111/j.1365-2141.1973.tb05728.x.
3
A buffered chromic chloride method of attaching antigens to red cells: use in haemagglutination.一种将抗原附着于红细胞的缓冲氯化铬方法：用于血凝反应。
J Immunol Methods. 1974 May;5(1):91-6. doi: 10.1016/0022-1759(74)90050-7.
4
Letter: Detection and measurement of factor VIII antibodies in an agarose gel: a modified method.信函：琼脂糖凝胶中因子 VIII 抗体的检测与测定：一种改良方法。
Br J Haematol. 1976 Jun;33(2):309. doi: 10.1111/j.1365-2141.1976.tb03543.x.
5
Coagulation in an agarose gel and its application to the detection and measurement of factor VIII antibodies.琼脂糖凝胶中的凝血及其在因子 VIII 抗体检测与测定中的应用。
Br J Haematol. 1975 Feb;29(2):329-40. doi: 10.1111/j.1365-2141.1975.tb01827.x.
6
Clinical observations and their relationship to laboratory findings in the haemophilias.血友病的临床观察及其与实验室检查结果的关系。
Thromb Diath Haemorrh. 1975 Dec 15;34(3):734-9.
7
The lupus anticoagulant.狼疮抗凝物
Arthritis Rheum. 1976 Nov-Dec;19(6):1244-8. doi: 10.1002/art.1780190603.
8
Haemophilia Centre Director's annual statistics for 1975.
Br J Haematol. 1977 Jul;36(3):447-9. doi: 10.1111/j.1365-2141.1977.tb00668.x.
9
Association between hepatitis B virus and essential mixed cryoglobulinemia.乙型肝炎病毒与原发性混合性冷球蛋白血症之间的关联。
N Engl J Med. 1977 Jun 30;296(26):1501-4. doi: 10.1056/NEJM197706302962605.
10
Isolation of IgG3 from normal human sera and from a patient with multiple myeloma by using protein A-sepharose 4B.利用蛋白A-琼脂糖4B从正常人血清和一名多发性骨髓瘤患者的血清中分离IgG3 。
Scand J Immunol. 1975;4(7):633-40. doi: 10.1111/j.1365-3083.1975.tb02671.x.