Michel S, Laval F
Biochimie. 1982 Aug-Sep;64(8-9):753-5. doi: 10.1016/s0300-9084(82)80124-7.
When mammalian cells are incubated with an uncoupler of oxidative phosphorylation prior to and during X-irradiation, the survival and the mutation frequency are markedly increased. This process requires protein synthesis and is inhibited when the cells are plated in the presence of a protease inhibitor (antipain or leupeptin). These results suggest the existence of an error-prone DNA repair process in X-irradiated mammalian cells.
当在X射线照射之前及照射过程中，将哺乳动物细胞与氧化磷酸化解偶联剂一起孵育时，细胞存活率和突变频率会显著增加。此过程需要蛋白质合成，并且当细胞在蛋白酶抑制剂（抗蛋白酶或亮抑蛋白酶肽）存在的情况下铺板时会受到抑制。这些结果表明，在经X射线照射的哺乳动物细胞中存在一种易出错的DNA修复过程。
