Hemminki K, Mutanen P, Saloniemi I, Niemi M L, Vainio H
Br Med J (Clin Res Ed). 1982 Nov 20;285(6353):1461-3. doi: 10.1136/bmj.285.6353.1461.
Spontaneous abortions in hospital sterilising staff were analysed using data from a postal questionnaire and a hospital discharge register. The study included all the sterilising staff employed in Finnish hospitals in 1980; the controls were nursing auxiliaries. Data from the questionnaire showed that the frequency of spontaneous abortions was 11.3% for the sterilising staff and 10.6% for the nursing auxiliaries. When the staff were concerned in sterilising procedures during their pregnancy the frequency was 16.7% compared with 5.6% for the non-exposed pregnancies. Adjustment for age, parity, decade of pregnancy, smoking habits, and intake of coffee and alcohol did not affect the differences. The increased frequency of spontaneous abortion correlated with exposure to ethylene oxide but not with exposure to glutaraldehyde or to formaldehyde. Analysis of spontaneous abortions from the hospital discharge register confirmed the findings. Thus the results from the two independent analyses suggest that exposure to ethylene oxide in hospitals may carry a risk of spontaneous abortion among sterilising staff.
利用邮寄问卷调查数据和医院出院登记数据，对医院消毒工作人员的自然流产情况进行了分析。该研究纳入了1980年芬兰医院雇佣的所有消毒工作人员；对照组为助理护士。问卷调查数据显示，消毒工作人员的自然流产发生率为11.3%，助理护士为10.6%。工作人员在孕期参与消毒程序时，自然流产发生率为16.7%，未接触消毒程序的孕期发生率为5.6%。对年龄、产次、怀孕年代、吸烟习惯以及咖啡和酒精摄入量进行校正后，差异依然存在。自然流产发生率的增加与环氧乙烷暴露有关，但与戊二醛或甲醛暴露无关。对医院出院登记中的自然流产情况分析证实了上述结果。因此，两项独立分析的结果表明，医院中环氧乙烷暴露可能会使消毒工作人员面临自然流产风险。
