Eichenbaum H, Clegg R A, Feeley A
Exp Neurol. 1983 Feb;79(2):434-51. doi: 10.1016/0014-4886(83)90224-8.
Selective patterns of behavioral deficits were observed on tests of spatial or olfactory learning after different cortical lesions in rats. The results clearly distinguished functional subdivisions of the rodent prefrontal cortex: Rats with lesions of the prefrontal cortex that primarily involve the dorsal bank of the rhinal sulcus were impaired selectively and exhibited increased perseveration of responses in a go, no-go odor discrimination task. In contrast, rats with lesions of the region of prefrontal cortex situated along the medial cortical wall were impaired selectively and exhibited increased perseveration of responses in a spatial delayed alteration task. These behavioral deficits were similar in magnitude and quality to those found in monkeys after discrete ablations of frontal lobe regions that are argued to be homologous prefrontal subdivisions.
在对大鼠进行不同的皮层损伤后，在空间或嗅觉学习测试中观察到了行为缺陷的选择性模式。结果清楚地区分了啮齿动物前额叶皮层的功能亚区：主要累及鼻沟背侧缘的前额叶皮层损伤的大鼠在去/不去气味辨别任务中表现出选择性受损，并表现出反应持续性增加。相比之下，沿内侧皮质壁的前额叶皮层区域损伤的大鼠在空间延迟交替任务中表现出选择性受损，并表现出反应持续性增加。这些行为缺陷在程度和性质上与在猴子身上进行离散额叶区域切除后发现的缺陷相似，这些区域被认为是同源的前额叶亚区。
