子宫内膜癌中雌激素受体状态的肿瘤内异质性
Intra-tumoural variation of oestrogen receptor status in endometrial cancer.
作者信息
Castagnetta L, Lo Casto M, Mercadante T, Polito L, Cowan S, Leake R E
出版信息
Br J Cancer. 1983 Feb;47(2):261-7. doi: 10.1038/bjc.1983.34.
Abstract
Soluble and nuclear oestrogen receptor status was determined in both the central and peripheral portions of tumour for 37 cases of adenocarcinoma of the endometrium. Of these, 29 had functional receptor in the peripheral biopsy, but only 19 retained functional receptor in the centre. Six of the 10 patients whose tumours showed this difference came from the group of 12 patients who were immediately post-menopausal (4.50 +/- 1.45 y post-menopausal age). Receptor status was not related to tumour classification into histological grades I and II. However, receptor-negative central biopsies were significantly more likely (P less than 0.05) to be Grade III. Early relapse was also related to a receptor-negative central biopsy.
摘要
对37例子宫内膜腺癌患者的肿瘤中央和外周部分进行了可溶性和核雌激素受体状态检测。其中，29例在外周活检中有功能性受体，但只有19例在中央仍保留功能性受体。肿瘤表现出这种差异的10例患者中有6例来自12例绝经后不久的患者组（绝经后年龄4.50±1.45岁）。受体状态与肿瘤组织学分级为I级和II级无关。然而，受体阴性的中央活检更有可能（P<0.05）为III级。早期复发也与受体阴性的中央活检有关。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Steroid hormone receptors in adenocarcinoma of the endometrium.子宫内膜腺癌中的类固醇激素受体。
Gynecol Oncol. 1980 Oct;10(2):152-61. doi: 10.1016/0090-8258(80)90077-3.
3
Soluble and nuclear oestrogen receptor status in human breast cancer in relation to prognosis.人类乳腺癌中可溶性和核雌激素受体状态与预后的关系
Br J Cancer. 1981 Jan;43(1):67-71. doi: 10.1038/bjc.1981.9.
4
Oestrogen-receptor status and endocrine therapy of breast cancer: response rates and status stability.雌激素受体状态与乳腺癌内分泌治疗：缓解率及状态稳定性
Br J Cancer. 1981 Jan;43(1):59-66. doi: 10.1038/bjc.1981.8.
5
Do estrogen and progesterone receptors (E2R and PR) in metastasizing endometrial cancers predict the response to gestagen therapy?转移性子宫内膜癌中的雌激素和孕激素受体（E2R和PR）能否预测对孕激素治疗的反应？
Acta Obstet Gynecol Scand. 1980;59(2):155-9. doi: 10.3109/00016348009154633.
6
Unoccupied nuclear receptors for estrogen in human endometrial tissue.人子宫内膜组织中未被占据的雌激素核受体。
J Clin Endocrinol Metab. 1980 Mar;50(3):541-5. doi: 10.1210/jcem-50-3-541.
7
Intratumoral variation of cytoplasmic and nuclear estrogen receptor concentrations in human mammary carcinoma.人乳腺癌中细胞质和细胞核雌激素受体浓度的瘤内变异
Eur J Cancer (1965). 1980 Jan;16(1):59-65. doi: 10.1016/0014-2964(80)90108-5.
8
Estradiol and progesterone receptors in human endometrium: normal and abnormal menstrual cycles and early pregnancy.人子宫内膜中的雌二醇和孕酮受体：正常与异常月经周期及早期妊娠
Am J Obstet Gynecol. 1980 Mar 1;136(5):646-51. doi: 10.1016/0002-9378(80)91018-2.
9
Sex steroid receptors in gynecologic cancer.妇科癌症中的性类固醇受体
Obstet Gynecol. 1980 May;55(5):648-52.
10
Oestrogen receptors and breast cancer: current status.雌激素受体与乳腺癌：现状
Br J Surg. 1980 Mar;67(3):153-69. doi: 10.1002/bjs.1800670302.
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