Leake R E, Laing L, Calman K C, Macbeth F R, Crawford D, Smith D C
Br J Cancer. 1981 Jan;43(1):59-66. doi: 10.1038/bjc.1981.8.
The concentration of cellular oestrogen receptor (RE) was measured in both the soluble and nuclear-pellet fractions of biopsies from 1,000 breast cancers. Data suggest that functional steroid RE is always in equilibrium between the soluble and nuclear fractions. However, biopsies from only one-third of patients contained detectable amounts of high-affinity RE in both fractions. Thirty patients out of 42 (71%) whose biopsies contained RE in both fractions, showed objective remission after receiving some form of hormonal manipulation as sole treatment. Response rates in the other categories ranged from 9% for those whose biopsies contained no detectable RE to 24% for those who displayed soluble RE alone. The presence of RE in both fractions of primary disease, whereas RE-negativity was maintained during progression from primary to secondary disease. Other aspects of RE status in relation to stage of disease are analysed.
对1000例乳腺癌活检组织的可溶性和细胞核沉淀部分中的细胞雌激素受体（RE）浓度进行了测定。数据表明，功能性类固醇RE在可溶性和细胞核部分之间始终处于平衡状态。然而，只有三分之一患者的活检组织在这两个部分中都含有可检测到的高亲和力RE。42例活检组织在两个部分中都含有RE的患者中，有30例（71%）在接受某种形式的激素治疗作为唯一治疗后出现客观缓解。其他类别患者的缓解率从活检组织中未检测到RE的患者的9%到仅显示可溶性RE的患者的24%不等。原发性疾病的两个部分中均存在RE，而在从原发性疾病进展到继发性疾病的过程中，RE阴性得以维持。分析了RE状态与疾病分期相关的其他方面。
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