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含铅塑料膜队列中与苯暴露相关的白血病风险:I. 死亡率更新及暴露分布

Leukemia risk associated with benzene exposure in the pliofilm cohort: I. Mortality update and exposure distribution.

作者信息

Paxton M B, Chinchilli V M, Brett S M, Rodricks J V

机构信息

American Petroleum Institute, Washington, D.C. 20005.

出版信息

Risk Anal. 1994 Apr;14(2):147-54. doi: 10.1111/j.1539-6924.1994.tb00039.x.

Abstract

The National Institute of Occupational Safety and Health (NIOSH) recently completed a vital status update adding 6 years of observation on the rubber workers known as the Pliofilm cohort. Using traditional standardized mortality ratio (SMR) analysis, we investigate the impact of the additional information gathered in the NIOSH update. We also compare the effect of using three sets of job-, plant-, and year-specific exposure estimates on the evaluation of benzene's leukemogenicity. The lack of any additional cases of multiple myeloma does not support trends toward elevated risks for this endpoint (as had been observed earlier), and there is no indication of increased incidences of solid tumors (as predicted by animal studies). Qualitatively, which exposure estimates are used does not alter the conclusions. The data added in the update did not greatly modify the estimated relative risk of leukemia associated with benzene exposure, but did confirm previous findings that occupational exposure to high concentrations had leukemogenic potential. The fact that leukemia has not been observed in any individual who started employment in Pliofilm production after 1950 suggests that the observed leukemia cases could be a response to very high levels of benzene exposure that occurred during the early years of this manufacturing process.

摘要

美国国家职业安全与健康研究所(NIOSH)最近完成了一项生命状况更新,对被称为“普利菲姆队列”的橡胶工人增加了6年的观察。我们使用传统的标准化死亡比(SMR)分析方法,研究了NIOSH更新中收集的额外信息所产生的影响。我们还比较了使用三组特定工作、工厂和年份的暴露估计值对评估苯的致白血病性的效果。未发现新增的多发性骨髓瘤病例,这并不支持该终点风险升高的趋势(如早期观察到的那样),也没有迹象表明实体瘤发病率增加(如动物研究预测的那样)。定性地说,使用哪种暴露估计值并不会改变结论。更新中增加的数据并没有大幅改变与苯暴露相关的白血病估计相对风险,但确实证实了先前的发现,即职业性接触高浓度苯具有致白血病潜力。1950年后开始在普利菲姆生产部门工作的任何人都未患白血病,这一事实表明,观察到的白血病病例可能是对该制造过程早期极高水平苯暴露的一种反应。

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