Gould S F, Shannon J M, Cunha G R
Fertil Steril. 1983 Apr;39(4):520-4. doi: 10.1016/s0015-0282(16)46944-x.
With a technique of in vitro steroid autoradiography, the localization of nuclear estrogen binding sites has been studied in ovarian endometriotic foci from untreated patients in both the follicular and luteal phases of the cycle. Unlike the uterine endometrium, which displays cyclic changes in estrogen binding sites, the endometriotic foci show no such changes in the localization of estrogen binding sites. Throughout the cycle, a marked degree of estrogen binding is present in the stromal cells of the endometriotic foci, while in the uterine endometrium stromal binding sites are seen only during the proliferative phase and not during the secretory phase of the cycle. The glandular epithelium of the endometriotic foci displays a patchy localization of nuclear estrogen binding sites at all stages, while the glandular epithelium of the uterus is strongly positive during the proliferative phase but displays no estrogen binding sites during the secretory phase of the cycle. Thus, the endometriotic foci appear to respond differently to ovarian hormones, both in terms of the modulation of estrogen binding and in terms of glandular histology.
采用体外类固醇放射自显影技术，研究了未治疗患者在月经周期卵泡期和黄体期卵巢子宫内膜异位病灶中核雌激素结合位点的定位。与显示雌激素结合位点呈周期性变化的子宫内膜不同，子宫内膜异位病灶在雌激素结合位点的定位上没有这种变化。在整个月经周期中，子宫内膜异位病灶的基质细胞中存在显著程度的雌激素结合，而在子宫内膜中，基质结合位点仅在增殖期可见，在分泌期则不可见。子宫内膜异位病灶的腺上皮在所有阶段均显示核雌激素结合位点的斑片状定位，而子宫的腺上皮在增殖期呈强阳性，但在分泌期则不显示雌激素结合位点。因此，子宫内膜异位病灶在雌激素结合的调节和腺组织学方面似乎对卵巢激素有不同的反应。
