Shinomura Y, Saito R, Himeno S, Kurokawa M, Hamabe S, Takahashi S, Tarui S
Horm Metab Res. 1983 Jan;15(1):15-9. doi: 10.1055/s-2007-1018616.
The distribution of immunoreactive secretin in acid extracts of the alimentary tract of the rat was determined. It was found to be contained in higher concentrations in the duodenum and in the terminal ileum than in other parts of the intestine. To elucidate the possible role of secretin contained in the terminal ileum, this part of the intestine was perfused with hydrochloric acid, a potent secretin secretagogue, and changes in plasma immunoreactive secretin levels and in pancreatic secretion were investigated in anaesthetized rats. Plasma immunoreactive secretin was increased from 65 +/- 5 pg/ml to 108 +/- 13 pg/ml during a 10 minutes perfusion with hydrochloric acid. This was significantly higher than that of saline perfusion but significantly lower than that of duodenal perfusion with hydrochloric acid. Acid perfusion of the terminal ileum also caused a three-fold increase in pancreatic flow rate and a twofold increase in bicarbonate concentration. These results suggest that the terminal ileum, through release of secretin, might play a role in regulating the pancreatic secretion of water and bicarbonate in response to changes in intraluminal fluids in the distal intestine in the rat.
测定了大鼠消化道酸提取物中免疫反应性促胰液素的分布。结果发现，十二指肠和回肠末端中促胰液素的浓度高于肠道其他部位。为了阐明回肠末端中促胰液素的可能作用，用强效促胰液素分泌剂盐酸对该肠段进行灌注，并在麻醉大鼠中研究血浆免疫反应性促胰液素水平和胰腺分泌的变化。在用盐酸灌注10分钟期间，血浆免疫反应性促胰液素从65±5 pg/ml增加到108±13 pg/ml。这显著高于生理盐水灌注组，但显著低于十二指肠盐酸灌注组。回肠末端的酸灌注还导致胰腺流速增加三倍，碳酸氢盐浓度增加两倍。这些结果表明，回肠末端可能通过释放促胰液素，在调节大鼠远端肠道腔内液体变化时胰腺水和碳酸氢盐的分泌中发挥作用。
