Conte A, Roca P, Genestar C, Grases F
Faculty of Sciences, University of the Balears Islands, Palma de Mallorca, Spain.
Nephron. 1989;52(2):162-5. doi: 10.1159/000185621.
Uric acid is implicated in calcium oxalate kidney stone formation. Conspicuously so far, two hypotheses have been proposed: direct induction of calcium oxalate precipitation by uric acid, and uric acid as anti-inhibitor by binding urinary glycosaminoglycans (GAGS). The aim of this work is to evaluate uric acid and the relationship with GAGS in a group of patients with calcium oxalate lithiasis, and in a control group for detecting possible differences between the two groups. It was found that the lower concentration of GAGS in stone formers could impede their inhibitory activity on the heterogeneous nucleation of uric acid in calcium stone formation.
尿酸与草酸钙肾结石的形成有关。迄今为止，已有两种显著的假说被提出：尿酸直接诱导草酸钙沉淀，以及尿酸通过结合尿糖胺聚糖（GAGs）作为抗抑制剂。这项工作的目的是评估一组草酸钙结石患者以及一个对照组中尿酸及其与GAGs的关系，以检测两组之间可能存在的差异。研究发现，结石形成者中较低浓度的GAGs可能会阻碍其对尿酸在钙结石形成中异质成核的抑制活性。
