Jelkmann W, Kurtz A, Bauer C
Pflugers Arch. 1983 Feb;396(2):174-5. doi: 10.1007/BF00615522.
In order to test the hypothesis that the early cessation of erythropoietin (Ep) production during hypobaric hypoxia is induced by lowered food intake, we have compared the plasma Ep titer of rats after exposure to continuous hypoxia (42.6 kPa = 7000 m altitude) for 4 days with that in fed or fasted rats after exposure to discontinuous hypoxia. We found that plasma Ep was rather low after 4 days of continuous hypoxia. However, the Ep titer significantly rose again, when rats were maintained normoxic for 18 h and then exposed to repeated hypoxia for 6 h. Because this was also found in rats which were deprived of food during the normoxic interval and the second hypoxic period, we conclude that the fall of the Ep titer during continuous hypoxia is not primarily due to reduced food intake. In addition, our findings show that fasting per se lowers the Ep-response to hypoxia in normal rats but not exhypoxic rats.
为了检验下述假设，即在低压缺氧期间促红细胞生成素（Ep）生成的早期停止是由食物摄入量降低所诱导的，我们将连续缺氧（42.6 kPa = 7000米海拔）4天后大鼠的血浆Ep滴度与间断缺氧后喂食或禁食大鼠的血浆Ep滴度进行了比较。我们发现，连续缺氧4天后血浆Ep相当低。然而，当大鼠在常氧条件下维持18小时然后再次暴露于缺氧环境6小时时，Ep滴度再次显著升高。由于在常氧间隔期和第二次缺氧期剥夺食物的大鼠中也发现了这一情况，我们得出结论，连续缺氧期间Ep滴度的下降并非主要归因于食物摄入量减少。此外，我们的研究结果表明，禁食本身会降低正常大鼠对缺氧的Ep反应，但不会降低缺氧大鼠的Ep反应。
