Anagnostou A, Schade S, Ashkinaz M, Barone J, Fried W
Blood. 1977 Dec;50(6):1093-7.
The effects of protein deprivation on erythropoietin (Ep) production were studied. The posthypoxia plasma Ep levels of rats fed a protein-free diet for only 1 day prior to being exposed to 0.5 atmosphere for 7 hr were significantly lower than those of comparably hypoxic rats maintained on a normal diet. The postthypoxia plasma Ep levels were even lower in rats kept on protein-depleted diets for longer periods of time. Rats fed diets with 0.5%, 5% or 12% protein content for 6 days had lower posthypoxia plasma Ep levels than those fed a normal diet (20% protein content). When a single protein meal was force-fed to protein-deprived rats 0-4 hr after initiating the exposure to hypoxia, the posthypoxia plasma Ep levels were significantly higher than in protein-deprived rats that were fed water or dextrose. The posthypoxia plasma Ep titers of protein-deprived rats fed protein 4-8 hr prior to exposure to hypoxia did not differ significantly from those of protein-deprived rats. Although the posthypoxia plasma Ep levels of protein-deprived rats fed a hemolysate containing 0.8 g of hemoglobin 4 hr after beginning hypoxia were greater than those of protein-deprived rats fed only water, the rate of oxygen consumption in these two groups did not differ. We conclude that, in addition to its response to the availability of oxygen, Ep production is infl,enced by the availability of amino acids.
研究了蛋白质缺乏对促红细胞生成素（Ep）产生的影响。在暴露于0.5个大气压7小时之前仅1天饲喂无蛋白饮食的大鼠，其低氧后血浆Ep水平显著低于维持正常饮食的同等低氧大鼠。长时间维持蛋白质缺乏饮食的大鼠，其低氧后血浆Ep水平更低。饲喂蛋白质含量为0.5%、5%或12%的饮食6天的大鼠，其低氧后血浆Ep水平低于饲喂正常饮食（蛋白质含量20%）的大鼠。当在开始低氧暴露后0 - 4小时给蛋白质缺乏的大鼠强制喂食一顿单一的蛋白质餐时，低氧后血浆Ep水平显著高于喂食水或葡萄糖的蛋白质缺乏大鼠。在低氧暴露前4 - 8小时喂食蛋白质的蛋白质缺乏大鼠，其低氧后血浆Ep滴度与蛋白质缺乏大鼠没有显著差异。尽管在低氧开始4小时后给蛋白质缺乏的大鼠喂食含有0.8克血红蛋白的溶血产物，其低氧后血浆Ep水平高于仅喂食水的蛋白质缺乏大鼠，但这两组的耗氧率没有差异。我们得出结论，除了对氧气可用性的反应外，Ep的产生还受氨基酸可用性的影响。
