Stemhagen A, Slade J, Altman R, Bill J
Am J Epidemiol. 1983 Apr;117(4):443-54. doi: 10.1093/oxfordjournals.aje.a113562.
A retrospective case-control study was conducted to identify occupational risk factors associated with primary liver cancer in New Jersey, with particular focus on agricultural occupations and pesticide exposures. Hospital record room, tumor registry, and death certificate searches for the diagnosis of primary liver cancer resulted in identification of 959 cases of which 335 were subsequently confirmed. Interviews were completed for 265 persons with liver cancer diagnosed between January 1, 1975 and March 1, 1980 and for 530 matched controls; 96% of all interviews were conducted with family members of deceased or incompetent study subjects. Analyses of employment in agricultural occupations identified male farm laborers as having an odds ratio of 1.89 (95% confidence interval (CI) 1.19-3.00). An estimated relative risk of 3.20 (CI 1.11-9.21) was found for males engaged in winemaking. Among nonagricultural occupations, elevated risks were found for males working as bartenders and those employed in eating and drinking places, laundries and dry cleaning services, and gasoline service stations. An elevated risk of liver cancer was also associated with females employed as cleaning service workers. Hepatitis and cirrhosis could not be evaluated as risk factors in this study. Dose-response trends by level of alcohol consumption were found for both males and females.
开展了一项回顾性病例对照研究，以确定新泽西州与原发性肝癌相关的职业风险因素，特别关注农业职业和农药暴露情况。通过医院病历室、肿瘤登记处及死亡证明查找原发性肝癌诊断信息，共识别出959例病例，其中335例随后得到确诊。对1975年1月1日至1980年3月1日期间诊断为肝癌的265人及530名匹配对照进行了访谈；所有访谈中有96%是与已故或无行为能力研究对象的家庭成员进行的。对农业职业就业情况的分析表明，男性农场工人的优势比为1.89（95%置信区间[CI]为1.19 - 3.00）。从事酿酒工作的男性估计相对风险为3.20（CI为1.11 - 9.21）。在非农业职业中，发现男性酒保以及在餐饮场所、洗衣店和干洗服务店、加油站工作的男性风险升高。肝癌风险升高还与女性清洁服务工人有关。在本研究中，无法将肝炎和肝硬化评估为风险因素。发现男性和女性饮酒量的剂量反应趋势。
