Mamoli B, Dal-Bianco P, Zeitlhofer K
Eur Neurol. 1983;22(1):29-34. doi: 10.1159/000115533.
The effect of dantrolene sodium, using a dosage of 120 mg/day, was investigated in 3 patients suffering from myotonic dystrophy. These patients showed a marked reversible deterioration of the clinical symptoms, caused by a reduction of the isometric strength. Dantrolene sodium showed no influence on myotonic discharges and on the latency of the electrical and mechanical muscle response of the adductor pollicis muscle after electrical stimulation of the ulnar nerve. On the other hand a shortening of the relaxation time (in 2 patients) could be observed. The effect of dantrolene sodium on the contractile mechanism without having any influence on the electrical activity is confirmed. Although the relaxation time is shortened, a clinical deterioration is observed, caused by a reduction of the strength. This phenomenon can be explained by a reduction of the calcium release from the sarcoplasmic reticulum after drug application.
研究了3例肌强直性营养不良患者使用剂量为120毫克/天的丹曲林钠的效果。这些患者因等长肌力降低而出现临床症状明显的可逆性恶化。丹曲林钠对肌强直放电以及尺神经电刺激后拇内收肌的电肌肉反应和机械肌肉反应的潜伏期均无影响。另一方面，可以观察到（2例患者）松弛时间缩短。丹曲林钠对收缩机制有影响而对电活动无影响这一点得到了证实。尽管松弛时间缩短，但由于肌力降低仍观察到临床恶化。这种现象可以用用药后肌浆网钙释放减少来解释。
