多发性硬化症病程中寡克隆模式的序列变化。
Sequential changes in oligoclonal patterns during the course of multiple sclerosis.
作者信息
Thompson E J, Kaufmann P, Rudge P
出版信息
J Neurol Neurosurg Psychiatry. 1983 Feb;46(2):115-8. doi: 10.1136/jnnp.46.2.115.
Abstract
The majority of patients with multiple sclerosis have an abnormality of their spinal fluid immunoglobulins. This alteration is manifested as patterns of diffuse protein bands in the gamma globulin region following electrophoresis. This pattern has been termed one of restricted heterogeneity, or an oligoclonal pattern. We have found changes in the banding pattern of some patients studied longitudinally. Since the significance of these findings may be relevant to the pathogenesis of this notoriously waxing and waning disease, we discuss the importance of methodologies as well as the concept that IgM and IgA may be relevant to the interpretation of these observations.
摘要
大多数多发性硬化症患者的脑脊液免疫球蛋白存在异常。这种改变表现为电泳后γ球蛋白区域弥漫性蛋白带的模式。这种模式被称为限制性异质性模式或寡克隆模式。我们发现一些纵向研究的患者的条带模式有变化。由于这些发现的意义可能与这种众所周知的病情反复的疾病的发病机制相关，我们讨论了方法学的重要性以及IgM和IgA可能与这些观察结果的解释相关的概念。
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本文引用的文献
1
DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.圆盘电泳。II. 方法及其在人血清蛋白中的应用。
Ann N Y Acad Sci. 1964 Dec 28;121:404-27. doi: 10.1111/j.1749-6632.1964.tb14213.x.
2
Isoelectric focusing of IgG eluted from multiple sclerosis and subacute sclerosing panencephalitis brains.从多发性硬化症和亚急性硬化性全脑炎患者大脑中洗脱的IgG的等电聚焦。
Nature. 1980 Sep 25;287(5780):335-7. doi: 10.1038/287335a0.
3
Immunological changes in multiple sclerosis.多发性硬化症的免疫学变化
Nature. 1980 Sep 25;287(5780):275-6. doi: 10.1038/287275a0.
4
Isoelectric focusing--a new approach to the study of immune complexes.等电聚焦——研究免疫复合物的一种新方法。
J Immunol Methods. 1980;35(3-4):297-306. doi: 10.1016/0022-1759(80)90256-2.
5
6
Comparison of agar gel electrophoresis and isoelectric focusing in multiple sclerosis and subacute sclerosing panencephalitis.琼脂凝胶电泳与等电聚焦在多发性硬化症和亚急性硬化性全脑炎中的比较
Ann Neurol. 1981 Jan;9(1):34-41. doi: 10.1002/ana.410090107.
7
[A new micro-electrophoretic proceedure for untreated liquor cerebrospinalis. Differences in the pherogram of native and concentrated proteins. Studies on the protein electrophoresis of liquor cerebrospinalis with cellulose acetate membranes, II (author's transl)].[一种用于未经处理的脑脊液的新型微电泳方法。天然蛋白和浓缩蛋白电泳图谱的差异。用醋酸纤维素膜对脑脊液进行蛋白质电泳的研究，II（作者译）]
Z Klin Chem Klin Biochem. 1974 Feb;12(2):73-80.
8
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