慢性炎症性肠病中补体对吞噬细胞的激活不足？中性粒细胞对补体裂解产物C5a的趋化作用。
Subnormal activation of phagocytes by complement in chronic inflammatory bowel disease? Neutrophil chemotaxis to complement split product C5a.
作者信息
Elmgreen J
出版信息
Gut. 1984 Jul;25(7):737-42. doi: 10.1136/gut.25.7.737.
Abstract
The capacity of circulating phagocytes for activation by complement was investigated in consecutive, untreated cases of chronic inflammatory bowel disease. The major complement derived chemotactic factor, C5a, served as chemoattractant in dose response studies of neutrophil chemotaxis. A similar, significantly decreased sensitivity and peak response was revealed in patients with Crohn's disease and ulcerative colitis. This subnormal function of neutrophils could be shown even in cases of complete clinical remission. Chemotactic response to casein and spontaneous motility was within the normal range showing an unaffected basic cell function of neutrophils in the patients. The study shows a dysfunction of phagocytic cells, related to potentially important phlogistic mediators, in chronic inflammatory bowel disease.
摘要
在未经治疗的连续性慢性炎症性肠病病例中，研究了循环吞噬细胞被补体激活的能力。主要的补体衍生趋化因子C5a，在中性粒细胞趋化性的剂量反应研究中用作趋化剂。在克罗恩病和溃疡性结肠炎患者中发现了类似的、显著降低的敏感性和峰值反应。即使在临床完全缓解的病例中，也能显示出中性粒细胞的这种功能低下。对酪蛋白的趋化反应和自发运动在正常范围内，表明患者中性粒细胞的基本细胞功能未受影响。该研究表明，在慢性炎症性肠病中，吞噬细胞存在功能障碍，这与潜在的重要炎症介质有关。
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