Dana-Haeri J, Richens A
Epilepsia. 1983 Jun;24(3):377-81. doi: 10.1111/j.1528-1157.1983.tb04901.x.
The effect of high and low doses of norethisterone on seizure frequency was studied in nine epileptic patients, aged 20-30 years. All patients satisfied the defined criteria of having catamenial exacerbation. The study was double blind, placebo controlled, and randomised. Each patient was followed through four menstrual cycles with each drug dose and also with placebo. The results of this study suggest that norethisterone is not effective in the control of seizures associated with the menstrual period.
研究了高剂量和低剂量炔诺酮对9名年龄在20至30岁之间的癫痫患者癫痫发作频率的影响。所有患者均符合经期发作加剧的既定标准。该研究为双盲、安慰剂对照且随机分组。每位患者在服用每种药物剂量以及服用安慰剂的情况下，均经历了四个月经周期的观察。这项研究的结果表明，炔诺酮在控制与月经周期相关的癫痫发作方面无效。
