Turani H, Levi J, Zevin D, Kessler E
Isr J Med Sci. 1983 Apr;19(4):332-7.
The histopathological changes in the livers of 11 patients treated with alkylated and nonalkylated anabolic androgenic steroids are presented. The histological changes in the liver included: proliferation of the bile ducts with or without cystic dilatation (9/11), peliosis (8/11), atypical hyperplasia of liver cells (2/11), and tumors (3/11). The latter included one case of cholangiocarcinoma, one of hepatocellular carcinoma, and one of combined cholangiocellular and hepatocellular carcinoma. The pathological changes in the liver in this series suggest a possible relationship between anabolic androgenic steroids and bile duct proliferation and/or cholangiocarcinoma.
本文呈现了11例接受烷基化和非烷基化合成代谢雄激素类固醇治疗患者肝脏的组织病理学变化。肝脏的组织学变化包括：胆管增生伴或不伴囊性扩张（9/11）、肝紫癜（8/11）、肝细胞非典型增生（2/11）以及肿瘤（3/11）。后者包括1例胆管癌、1例肝细胞癌以及1例胆管细胞和肝细胞联合癌。该系列研究中肝脏的病理变化提示合成代谢雄激素类固醇与胆管增生和/或胆管癌之间可能存在关联。
