Sehgal S N, Czerkawski H, Kudelski A, Pandev K, Saucier R, Vézina C
J Antibiot (Tokyo). 1983 Apr;36(4):355-61. doi: 10.7164/antibiotics.36.355.
A streptomycete was isolated from a Guatemala soil sample and found to inhibit Grampositive bacteria including mycobacteria. The antibiotic-producing microorganism was characterized, identified as a new species and named Streptomyces ravidus. The antibiotic principle was extracted with organic solvent from the mycelium, isolated in crystalline form and named ravidomycin. Ravidomycin is mainly active against Gram-positive bacteria including mycobacteria. It shows only weak activity against Gram-negative organisms and no activity against fungi. Ravidomycin exhibits potent antitumor activity against P388 lymphocytic leukemia, Colon 38 tumor and CD8F1 mammary tumor. Acute toxicity in mice is low.
从危地马拉土壤样本中分离出一种链霉菌，发现它能抑制包括分枝杆菌在内的革兰氏阳性菌。对这种产生抗生素的微生物进行了表征，鉴定为一个新物种，并命名为嗜热链霉菌。抗生素成分用有机溶剂从菌丝体中提取出来，以结晶形式分离出来，命名为嗜热霉素。嗜热霉素主要对包括分枝杆菌在内的革兰氏阳性菌有活性。它对革兰氏阴性菌只有微弱活性，对真菌无活性。嗜热霉素对P388淋巴细胞白血病、结肠38肿瘤和CD8F1乳腺肿瘤具有强大的抗肿瘤活性。对小鼠的急性毒性较低。
