拉维霉素（AY - 25,545），一种新型抗肿瘤抗生素。

Ravidomycin (AY-25,545), a new antitumor antibiotic.

作者信息

Sehgal S N, Czerkawski H, Kudelski A, Pandev K, Saucier R, Vézina C

出版信息

J Antibiot (Tokyo). 1983 Apr;36(4):355-61. doi: 10.7164/antibiotics.36.355.

DOI:10.7164/antibiotics.36.355

Abstract

A streptomycete was isolated from a Guatemala soil sample and found to inhibit Grampositive bacteria including mycobacteria. The antibiotic-producing microorganism was characterized, identified as a new species and named Streptomyces ravidus. The antibiotic principle was extracted with organic solvent from the mycelium, isolated in crystalline form and named ravidomycin. Ravidomycin is mainly active against Gram-positive bacteria including mycobacteria. It shows only weak activity against Gram-negative organisms and no activity against fungi. Ravidomycin exhibits potent antitumor activity against P388 lymphocytic leukemia, Colon 38 tumor and CD8F1 mammary tumor. Acute toxicity in mice is low.

摘要

从危地马拉土壤样本中分离出一种链霉菌，发现它能抑制包括分枝杆菌在内的革兰氏阳性菌。对这种产生抗生素的微生物进行了表征，鉴定为一个新物种，并命名为嗜热链霉菌。抗生素成分用有机溶剂从菌丝体中提取出来，以结晶形式分离出来，命名为嗜热霉素。嗜热霉素主要对包括分枝杆菌在内的革兰氏阳性菌有活性。它对革兰氏阴性菌只有微弱活性，对真菌无活性。嗜热霉素对P388淋巴细胞白血病、结肠38肿瘤和CD8F1乳腺肿瘤具有强大的抗肿瘤活性。对小鼠的急性毒性较低。