Kasting N W, Carr D B, Martin J B, Blume H, Bergland R
Can J Physiol Pharmacol. 1983 Apr;61(4):427-31. doi: 10.1139/y83-064.
Plasma and cerebrospinal fluid (CSF) concentrations of vasopressin (AVP) were measured in conscious sheep during fever induced by iv endotoxin. Body temperature and blood pressure were also measured. AVP concentrations increased in both CSF and plasma although increases were not parallel. AVP concentrations in CSF were significantly correlated to increases in body temperature whereas plasma AVP concentrations were not. Neither CSF nor plasma AVP concentrations were correlated with changes in blood pressure. These data indicate that there may be independent regulation of AVP release into plasma and CSF compartments and supports the idea that AVP may have several physiological functions to perform during fever.
在静脉注射内毒素诱导发热的清醒绵羊中，测量了血管加压素（AVP）的血浆和脑脊液（CSF）浓度。还测量了体温和血压。脑脊液和血浆中的AVP浓度均升高，尽管升高并不平行。脑脊液中的AVP浓度与体温升高显著相关，而血浆AVP浓度则不然。脑脊液和血浆中的AVP浓度均与血压变化无关。这些数据表明，AVP释放到血浆和脑脊液隔室中可能存在独立调节，并支持AVP在发热期间可能具有多种生理功能的观点。
