Payne C M, Glasser L
Am J Pathol. 1978 Sep;92(3):611-8.
The response of lymphocytes containing cytoplasmic inclusions called parallel tubular arrays (PTA) was determined after the administration of the glucocorticoid dexamethasone to 10 healthy volunteers. The percentage of these lymphocytes was found to increase during the lymphopenia induced by steroid administration. The size and number of parallel tubular arrays per cell showed no differences before and after steroid administration, indicating that the increase was a result of a change in the proportion of whole cells. This indicates, for the first time, that a morphologically defined population of lymphocytes from the normal peripheral circulation has been linked to a specific response, ie, steroid resistance. The possible mechanism of steroid resistance is discussed.
对10名健康志愿者给予糖皮质激素地塞米松后，测定了含有称为平行管状排列（PTA）的细胞质内含物的淋巴细胞的反应。发现在类固醇给药诱导的淋巴细胞减少期间，这些淋巴细胞的百分比增加。每个细胞的平行管状排列的大小和数量在类固醇给药前后没有差异，表明增加是全细胞比例变化的结果。这首次表明，来自正常外周循环的形态学定义的淋巴细胞群体与特定反应，即类固醇抵抗有关。讨论了类固醇抵抗的可能机制。
