Keating H J, Kundrat M
Veterans Affairs Medical Center, Des Moines, IA, USA.
J Pain Symptom Manage. 1996 Feb;11(2):126-30. doi: 10.1016/0885-3924(95)00149-2.
We tested a new nitrous oxide (N2O) delivery system to explore its usefulness in patient-controlled analgesia. Six patients with uncontrolled cancer-related pain were studied. Patients could give themselves inhalations of a fixed 50%/50% mixture of N2O and oxygen via mouthpiece or face mask. This therapy supplemented other available modalities, principally long-acting oral morphine. We found this strategy to be environmentally safe, well accepted by patients and staff, and effective in relieving pain. Ambient concentrations of N2O were measured and suggested that environmental exposure to caregivers was minimal and safe. No problems were encountered with family and staff acceptance of this modality. We suggest that this method may be a useful addition to pain control measures in cancer patients, and merits further study.
我们测试了一种新型一氧化二氮（N₂O）输送系统，以探究其在患者自控镇痛中的效用。研究了6名癌症相关疼痛未得到控制的患者。患者可通过咬嘴或面罩自行吸入固定比例为50%/50%的N₂O和氧气混合物。该疗法作为其他可用方式的补充，主要是长效口服吗啡。我们发现这种方法对环境安全，患者和工作人员都能很好地接受，并且在缓解疼痛方面有效。对环境中N₂O浓度进行了测量，结果表明护理人员的环境暴露风险极小且安全。在家人和工作人员对这种方式的接受方面未遇到问题。我们认为这种方法可能是癌症患者疼痛控制措施中的一项有益补充，值得进一步研究。
