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1
Altered sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA in ketotic diabetic rats.酮症糖尿病大鼠中肉碱棕榈酰转移酶对丙二酰辅酶A抑制作用的敏感性改变。
Biochem J. 1984 Apr 1;219(1):337-9. doi: 10.1042/bj2190337.
2
Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I.pH对丙二酰辅酶A抑制肉碱棕榈酰转移酶I的影响。
Biochem J. 1983 May 15;212(2):521-4. doi: 10.1042/bj2120521.
3
Increased sensitivity of carnitine palmitoyltransferase I activity to malonyl-CoA inhibition after preincubation of intact rat liver mitochondria with micromolar concentrations of malonyl-CoA in vitro.在体外将完整大鼠肝脏线粒体与微摩尔浓度的丙二酰辅酶A预孵育后，肉碱棕榈酰转移酶I活性对丙二酰辅酶A抑制作用的敏感性增加。
Biochem J. 1983 Mar 15;210(3):953-6. doi: 10.1042/bj2100953.
4
Involvement of hysteretic effects in the inhibition of carnitine palmitoyltransferase by malonyl-CoA.丙二酰辅酶A对肉碱棕榈酰转移酶抑制作用中的滞后效应参与情况。
Biochem J. 1984 Dec 15;224(3):1015-8. doi: 10.1042/bj2241015.
5
Effects of fasting and malonyl CoA on the kinetics of carnitine palmitoyltransferase and carnitine octanoyltransferase in intact rat liver mitochondria.禁食和丙二酰辅酶A对完整大鼠肝脏线粒体中肉碱棕榈酰转移酶和肉碱辛酰转移酶动力学的影响。
FEBS Lett. 1981 Sep 28;132(2):166-8. doi: 10.1016/0014-5793(81)81152-0.
6
Ethanol increases the sensitivity of carnitine palmitoyltransferase I to inhibition by malonyl-CoA in short-term hepatocyte incubations.在短期肝细胞培养中，乙醇会增加肉碱棕榈酰转移酶I对丙二酰辅酶A抑制作用的敏感性。
Biochim Biophys Acta. 1989 Apr 26;1002(3):405-8. doi: 10.1016/0005-2760(89)90358-5.
7
Reversible sensitization and desensitization of carnitine palmitoyltransferase I to inhibition by malonyl-CoA in isolated rat liver mitochondria. Significance for the mechanism of malonyl-CoA-induced sensitization.肉碱棕榈酰转移酶I在离体大鼠肝脏线粒体中对丙二酰辅酶A抑制作用的可逆性致敏和脱敏。对丙二酰辅酶A诱导致敏机制的意义。
Biochem J. 1983 Sep 15;214(3):1027-30. doi: 10.1042/bj2141027.
8
Sensitivity of carnitine acyltransferase I to malonly-CoA inhibition in isolated rat liver mitochondria is quantitatively related to hepatic malonyl-CoA concentration in vivo.在分离的大鼠肝脏线粒体中，肉碱酰基转移酶I对丙二酰辅酶A抑制作用的敏感性与体内肝脏丙二酰辅酶A浓度存在定量关系。
Biochem J. 1982 Jul 15;206(1):177-9. doi: 10.1042/bj2060177.
9
Hysteretic behaviour of carnitine palmitoyltransferase. The effect of preincubation with malonyl-CoA.肉碱棕榈酰转移酶的滞后行为。丙二酰辅酶A预温育的影响。
Biochem J. 1986 Jun 15;236(3):917-9. doi: 10.1042/bj2360917.
10
Time-dependence of inhibition of carnitine palmitoyltransferase I by malonyl-CoA in mitochondria isolated from livers of fed or starved rats. Evidence for transition of the enzyme between states of low and high affinity for malonyl-CoA.进食或饥饿大鼠肝脏分离线粒体中丙二酰辅酶A对肉碱棕榈酰转移酶I抑制作用的时间依赖性。该酶对丙二酰辅酶A的低亲和力和高亲和力状态之间转变的证据。
Biochem J. 1984 Mar 1;218(2):379-86. doi: 10.1042/bj2180379.

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1
ACC2 is expressed at high levels in human white adipose and has an isoform with a novel N-terminus [corrected].ACC2在人类白色脂肪中高水平表达，并且有一种具有新N端的同工型[已修正]。
PLoS One. 2009;4(2):e4369. doi: 10.1371/journal.pone.0004369. Epub 2009 Feb 3.
2
The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function.丙二酰辅酶A-长链酰基辅酶A轴在维持哺乳动物细胞功能中的作用
Biochem J. 1999 Nov 1;343 Pt 3(Pt 3):505-15.
3
Effect of membrane environment on the activity and inhibitability by malonyl-CoA of the carnitine acyltransferase of hepatic microsomal membranes.膜环境对肝微粒体膜肉碱酰基转移酶活性及丙二酰辅酶A抑制作用的影响
Biochem J. 1997 Mar 1;322 ( Pt 2)(Pt 2):435-40. doi: 10.1042/bj3220435.
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Mammalian mitochondrial beta-oxidation.哺乳动物线粒体β-氧化
Biochem J. 1996 Dec 1;320 ( Pt 2)(Pt 2):345-57. doi: 10.1042/bj3200345.
5
Involvement of hysteretic effects in the inhibition of carnitine palmitoyltransferase by malonyl-CoA.丙二酰辅酶A对肉碱棕榈酰转移酶抑制作用中的滞后效应参与情况。
Biochem J. 1984 Dec 15;224(3):1015-8. doi: 10.1042/bj2241015.
6
Cycloheximide blocks changes in rat liver carnitine palmitoyltransferase 1 activity in starvation.放线菌酮可阻止饥饿状态下大鼠肝脏肉碱棕榈酰转移酶1活性的变化。
Biochem J. 1984 Nov 15;224(1):201-6. doi: 10.1042/bj2240201.
7
Hepatic mitochondrial inner membrane properties and carnitine palmitoyltransferase A and B. Effect of diabetes and starvation.肝线粒体内膜特性以及肉碱棕榈酰转移酶A和B。糖尿病和饥饿的影响。
Biochem J. 1985 Dec 1;232(2):445-50. doi: 10.1042/bj2320445.
8
Hepatic mitochondrial inner-membrane properties, beta-oxidation and carnitine palmitoyltransferases A and B. Effects of genetic obesity and starvation.肝脏线粒体内膜特性、β-氧化以及肉碱棕榈酰转移酶A和B。遗传性肥胖和饥饿的影响。
Biochem J. 1986 Jan 15;233(2):427-33. doi: 10.1042/bj2330427.
9
Carnitine palmitoyltransferase in liver and five extrahepatic tissues in the rat. Inhibition by DL-2-bromopalmitoyl-CoA and effect of hypothyroidism.大鼠肝脏及五种肝外组织中的肉碱棕榈酰转移酶。DL-2-溴棕榈酰辅酶A的抑制作用及甲状腺功能减退的影响。
Biochem J. 1986 May 15;236(1):137-41. doi: 10.1042/bj2360137.
10
Hepatic carnitine palmitoyltransferase turnover and translation rates in fed, starved, streptozotocin-diabetic and diethylhexyl phthalate-treated rats.喂食、饥饿、链脲佐菌素诱导糖尿病及邻苯二甲酸二乙酯处理的大鼠肝脏中肉碱棕榈酰转移酶的周转和翻译速率
Biochem J. 1987 Sep 15;246(3):641-9. doi: 10.1042/bj2460641.

本文引用的文献

1
Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood.血液中D(-)-β-羟基丁酸和乙酰乙酸的酶法测定
Biochem J. 1962 Jan;82(1):90-6. doi: 10.1042/bj0820090.
2
The effect of fasting on the activity of liver carnitine palmitoyltransferase and its inhibition by malonyl-CoA.禁食对肝脏肉碱棕榈酰转移酶活性的影响及其被丙二酰辅酶A的抑制作用。
Biochim Biophys Acta. 1981 Sep 24;665(3):628-31. doi: 10.1016/0005-2760(81)90282-4.
3
Effects of fasting, adrenalectomy and streptozotocin-diabetes on sensitivity of hepatic carnitine acyltransferase to malonyl CoA.禁食、肾上腺切除及链脲佐菌素诱导的糖尿病对肝脏肉碱酰基转移酶对丙二酰辅酶A敏感性的影响。
FEBS Lett. 1981 Jul 6;129(2):225-8. doi: 10.1016/0014-5793(81)80170-6.
4
Evaluation of malonyl-CoA in the regulation of long-chain fatty acid oxidation in the liver. Evidence for an unidentified regulatory component of the system.肝脏中丙二酰辅酶A对长链脂肪酸氧化调节作用的评估。该系统存在未知调节成分的证据。
Biochem J. 1980 Dec 15;192(3):959-62. doi: 10.1042/bj1920959.
5
Differential inhibition of ketogenesis by malonyl-CoA in mitochondria from fed and starved rats.进食和饥饿大鼠线粒体中丙二酰辅酶A对生酮作用的差异抑制
Biochem J. 1980 Dec 15;192(3):955-8. doi: 10.1042/bj1920955.
6
Regulatory mechanism of ketogenesis by glucagon and insulin in isolated and cultured hepatocytes.胰高血糖素和胰岛素对分离培养肝细胞生酮作用的调节机制
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7
Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I.pH对丙二酰辅酶A抑制肉碱棕榈酰转移酶I的影响。
Biochem J. 1983 May 15;212(2):521-4. doi: 10.1042/bj2120521.
8
Activity state of the branched chain alpha-ketoacid dehydrogenase complex in heart, liver, and kidney of normal, fasted, diabetic, and protein-starved rats.正常、禁食、糖尿病及蛋白质缺乏大鼠心脏、肝脏和肾脏中支链α-酮酸脱氢酶复合体的活性状态
Biochem Biophys Res Commun. 1983 Feb 28;111(1):74-81. doi: 10.1016/s0006-291x(83)80119-3.
9
A spectrophotometric, enzymatic assay for D-3-hydroxybutyrate that is not dependent on hydrazine.一种不依赖肼的用于检测D-3-羟基丁酸的分光光度酶法测定。
Anal Biochem. 1983 Jun;131(2):478-82. doi: 10.1016/0003-2697(83)90201-4.
10
Effects of streptozotocin on carbohydrate and lipid metabolism in the rat.链脲佐菌素对大鼠碳水化合物和脂质代谢的影响。
Endocrinology. 1971 Sep;89(3):827-34. doi: 10.1210/endo-89-3-827.

酮症糖尿病大鼠中肉碱棕榈酰转移酶对丙二酰辅酶A抑制作用的敏感性改变。

Altered sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA in ketotic diabetic rats.

作者信息

Cook G A, Stephens T W, Harris R A

出版信息

Biochem J. 1984 Apr 1;219(1):337-9. doi: 10.1042/bj2190337.

DOI:10.1042/bj2190337
PMID:6426472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1153484/
Abstract

Carnitine palmitoyltransferase of liver mitochondria prepared from ketotic diabetic rats has a diminished sensitivity to inhibition by malonyl-CoA compared with carnitine palmitoyltransferase of mitochondria prepared from normal fed rats.

摘要

与从正常进食大鼠制备的线粒体肉碱棕榈酰转移酶相比，从酮症糖尿病大鼠制备的肝脏线粒体肉碱棕榈酰转移酶对丙二酸单酰辅酶A抑制的敏感性降低。