Chan S H, Day N E, Kunaratnam N, Chia K B, Simons M J
Int J Cancer. 1983 Aug 15;32(2):171-6. doi: 10.1002/ijc.2910320206.
This paper reports the results of 8 years of HLA typing of newly diagnosed nasopharyngeal carcinoma (NPC) patients among Chinese in Singapore, and compares the HLA profile of NPC cases with that of the normal Chinese population. Earlier results had indicated an association with A2 and BW46, but the heterogeneity of the earlier case series, which contained a proportion of long-term survivors, obscured other aspects of the relationship. In this paper, the risk associated with A2 (relative risk = 1.5) and BW46 (relative risk = 1.9) is confirmed, showing a much higher relative risk in the presence of both antigens, and a risk is also demonstrated for B17 (relative risk = 2.1). Relative risks of less than unity are observed for AII (relative risk = 0.5) and B13 (relative risk = 0.5). Data from family studies indicate the importance of the haplotype A2.BW46 in determining risk for NPC.
本文报告了对新加坡华人中新诊断的鼻咽癌（NPC）患者进行8年HLA分型的结果，并将NPC病例的HLA谱与正常华人人群的HLA谱进行了比较。早期结果表明与A2和BW46有关联，但早期病例系列存在异质性，其中包含一部分长期存活者，这掩盖了这种关系的其他方面。在本文中，与A2（相对风险=1.5）和BW46（相对风险=1.9）相关的风险得到了证实，在同时存在这两种抗原的情况下显示出更高的相对风险，并且还证明了B17存在风险（相对风险=2.1）。观察到AII（相对风险=0.5）和B13（相对风险=0.5）的相对风险小于1。家族研究数据表明单倍型A2.BW46在确定NPC风险中的重要性。
