Black H R, Zeevi G R, Silten R M, Walker Smith G J
Nephron. 1983;34(3):173-9. doi: 10.1159/000183005.
While cigarette smoking is felt to damage small vessels in organs not in direct contact with smoke, the kidney has not been considered a target organ. Sections of kidney and myocardium in 40 autopsied subjects without known disease which damage small vessels (21 smokers, 4 ex-smokers and 15 nonsmokers) were examined to determine if the percentage of intima (IP) was increased in small (less than 150 microns) and larger (150-550 microns) arterioles. In both organs and in all vessels, mean IP was significantly greater in smokers. The degree of increase did not correlate with smoking dosage (in pack-years) but did show a positive correlation with age in the kidney but not the heart. In the kidney, at all ages studied, IP was significantly increased in smokers compared to nonsmokers. We conclude that the kidney is another target organ of smoking. Whether this causes clinical disease is unknown.
虽然人们认为吸烟会损害未直接接触烟雾的器官中的小血管，但肾脏一直未被视为靶器官。对40名无已知小血管损伤疾病的尸检对象（21名吸烟者、4名既往吸烟者和15名不吸烟者）的肾脏和心肌切片进行检查，以确定小（小于150微米）和大（150 - 550微米）小动脉内膜百分比（IP）是否增加。在这两个器官以及所有血管中，吸烟者的平均IP均显著更高。增加程度与吸烟剂量（以包年计）无关，但在肾脏中与年龄呈正相关，在心脏中则不然。在肾脏中，在所研究的所有年龄段，吸烟者的IP均显著高于不吸烟者。我们得出结论，肾脏是吸烟的另一个靶器官。这是否会导致临床疾病尚不清楚。
