Fraioli B, Ferrante L, Celli P
J Neurosurg. 1983 Oct;59(4):590-5. doi: 10.3171/jns.1983.59.4.0590.
From a series of 207 patients with pituitary adenoma operated on by microsurgical technique from 1973 to February, 1982, the cases of nine young people whose symptoms had appeared between the ages of 11 and 15 years are presented. The most important data are that all the children were pubertal and that in seven the tumor was, or later became, invasive. By contrast, the tumor was enclosed in eight of nine other patients whose symptoms manifested between the ages of 16 and 20 years, and in 152 of the remaining 189 patients whose symptoms appeared after the age of 20 years. Considering the gravity of the disease treated, the results in this series may be termed encouraging. The treatment was multidisciplinary: starting with surgery, followed by radiotherapy, endocrine replacement therapy, and, in adenomas secreting prolactin and/or growth hormone, medical therapy with bromocriptine. The divergence between authors on the subject of childhood adenomas, especially as to whether they are more often invasive or enclosed, could be overcome, at least in part, if the term "pediatric age" were unequivocally defined and if there were an agreed distinction between puberty and childhood on the one hand and puberty and adolescence on the other.
在1973年至1982年2月期间，采用显微外科技术对207例垂体腺瘤患者进行了手术治疗，本文报告了9例年龄在11至15岁之间出现症状的青少年患者的病例。最重要的数据是，所有儿童均处于青春期，其中7例肿瘤具有侵袭性或后来变为侵袭性。相比之下，在年龄在16至20岁之间出现症状的另外9例患者中，有8例肿瘤被包膜包裹；在其余189例年龄在20岁以后出现症状的患者中，有152例肿瘤被包膜包裹。考虑到所治疗疾病的严重性，该系列的治疗结果可谓令人鼓舞。治疗是多学科的：首先是手术，然后是放疗、内分泌替代治疗，对于分泌催乳素和/或生长激素的腺瘤，采用溴隐亭进行药物治疗。如果能够明确界定“儿童期”这一术语，并且在青春期与儿童期以及青春期与青少年期之间达成一致的区分，那么作者们在儿童腺瘤问题上的分歧，尤其是关于它们是否更常具有侵袭性或被包膜包裹的分歧，至少可以部分得到解决。
