Hirata K, Kohgo Y, Araya H, Urushizaki Y, Matsumoto S, Ikeda A, Niitsu Y, Urushizaki I
Gan To Kagaku Ryoho. 1982 Jan;9(1):134-9.
A case of choriocarcinoma responding well to cis-diamminedichloroplatinum (CDDP) was reported. A 24-year-old male was admitted to our hospital with chief complaints of upper abdominal discomfort and gynecomastia. Physical findings on admission included solid tumors in the upper abdomen and bilateral inguinal regions. The chest X-ray picture showed numerous coin lesions, and abdominal ultrasound examination revealed a widespread metastasis in the retroperitoneum. Blood chemical analysis pointed out the high levels of LH, HCG, and beta-subunit of HCG. The pathological diagnosis of the biopsied inguinal mass was choriocarcinoma. The patient was treated with CDDP, vincristine and bleomycin according to the protocol of Einhorn. After three courses of this therapy, serum HCG level was normalized and pulmonary metastatic lesions were diminished, although abdominal ultrasound examination showed remnants of the decreased tumor masses. The patient was transferred to the urological department for further cytoreductive therapy.
报告了一例对顺二氯二氨铂（CDDP）反应良好的绒毛膜癌病例。一名24岁男性因上腹部不适和乳腺增生为主诉入院。入院时体格检查发现上腹部和双侧腹股沟区有实性肿瘤。胸部X线片显示多个硬币状病灶，腹部超声检查显示腹膜后广泛转移。血液化学分析显示促黄体生成素（LH）、人绒毛膜促性腺激素（HCG）及HCGβ亚单位水平升高。活检腹股沟肿块的病理诊断为绒毛膜癌。根据艾因霍恩方案，该患者接受了CDDP、长春新碱和博来霉素治疗。经过三个疗程的治疗，血清HCG水平恢复正常，肺部转移病灶减少，尽管腹部超声检查显示肿瘤肿块缩小后仍有残余。患者被转至泌尿外科进行进一步的细胞减灭治疗。
