Sioufi A, Pommier F
J Pharm Sci. 1980 Feb;69(2):167-9. doi: 10.1002/jps.2600690213.
The determination of alpha-tribenoside at concentrations down to 10 ng/ml and beta-tribenoside at concentrations down to 5 ng/ml in human plasma is described. After addition of an internal standard, alpha- and beta-tribenosides are extracted at basic pH into benzene. Both compounds are derivatized with N-heptafluorobutyrylimidazole. The derivatives are determined by GLC using a 63Ni-electron-capture detector.
本文描述了在人血浆中测定低至10 ng/ml的α-曲匹布通和低至5 ng/ml的β-曲匹布通的方法。加入内标后，α-和β-曲匹布通在碱性pH条件下被萃取到苯中。两种化合物均用N-七氟丁酰咪唑进行衍生化。衍生物通过使用63Ni电子捕获检测器的气相色谱法进行测定。
