Herzer P, Lemmel E M
Immunobiology. 1980 Apr;157(1):78-88. doi: 10.1016/S0171-2985(80)80065-9.
The effect of prednisolone and non-steroid anti-inflammatory drugs on PMNL (polymorphonuclear leucocytes) oxidative metabolism was quantified with a newly standardized NBT test, and it was investigated whether these effects correlate with phagocytosing capacity of PMNL. Prednisolone inhibits NBT reduction in dose dependency already at concentrations, which do not interfere with phagocytosis. Thus prednisolone dissociates phagocytosis and phagocytosis-associated oxidative metabolism. High doses of prednisolone also inhibit phagocytosis. These effects of prednisolone are still demonstrable when PMNL are washed after pre-incubation with the drug. The non-steroid anti-inflammatory drugs (indomethacin, phenylbutazone and pyrazinobutazone) inhibit phagocytosis and NBT reduction at equivalent doses. When PMNL are washed after incubation with the drugs, they regain normal capacity to phagocyse and to reduce NBT. It is suggested that these drugs inhibit phagocytosis directly, and consequently the phagocytosis-associated oxidative metabolism is suppressed.
采用一种新标准化的NBT试验定量测定了泼尼松龙和非甾体抗炎药对多形核白细胞（PMNL）氧化代谢的影响，并研究了这些影响是否与PMNL的吞噬能力相关。泼尼松龙在不干扰吞噬作用的浓度下就已经呈剂量依赖性地抑制NBT还原。因此，泼尼松龙使吞噬作用与吞噬作用相关的氧化代谢分离。高剂量的泼尼松龙也抑制吞噬作用。当用该药物预孵育后的PMNL被洗涤后，泼尼松龙的这些作用仍然可以显现。非甾体抗炎药（吲哚美辛、保泰松和吡嗪保泰松）在等效剂量下抑制吞噬作用和NBT还原。当与药物孵育后的PMNL被洗涤后，它们恢复了正常的吞噬和还原NBT的能力。提示这些药物直接抑制吞噬作用，因此吞噬作用相关的氧化代谢被抑制。
