Cassidy J T, Walker S E, Soderstrom S J, Petty R E, Sullivan D B
J Pediatr. 1978 Sep;93(3):416-20. doi: 10.1016/s0022-3476(78)81148-2.
Sera of children with juvenile rheumatoid arthritis and other connective tissue diseases were tested for antibodies to native DNA by a radiolabeled-binding assay. Normal values were obtained in 130 children with JRA, including 28 with uveitis and 14 with selective IgA deficiency. Normal values were also found in sera from children with dermatomyositis, scleroderma, polyarteritis, ankylosing spondylitis, and a variety of other nonconnective tissue diseases. The only sera with elevated DNA-binding assays were from children with systemic lupus erythematosus. On the basis of these data, increased levels of antibodies to native DNA distinguished patients with active SLE from children with JRA.
采用放射性标记结合试验检测青少年类风湿性关节炎及其他结缔组织病患儿血清中的抗天然DNA抗体。130例青少年类风湿性关节炎患儿检测结果正常，其中包括28例葡萄膜炎患儿和14例选择性IgA缺乏症患儿。皮肌炎、硬皮病、多动脉炎、强直性脊柱炎及其他多种非结缔组织病患儿的血清检测结果也正常。DNA结合试验结果升高的血清仅来自系统性红斑狼疮患儿。基于这些数据，抗天然DNA抗体水平升高可将活动性系统性红斑狼疮患者与青少年类风湿性关节炎患儿区分开来。
