一种序列系统发育研究策略。
A strategy for sequence phylogeny research.
作者信息
Sankoff D, Cedergren R J, McKay W
出版信息
Nucleic Acids Res. 1982 Jan 11;10(1):421-31. doi: 10.1093/nar/10.1.421.
Abstract
Minimal mutation trees, and almost minimal trees, are constructed from two data sets, one of phenylalanine tRNA sequences, and the other of 5S RNA sequences, from a diverse range of organisms. The two sets of results are mutually consistent. Trees representing previous evolutionary hypotheses are compared using a total weighted mutational distance criterion. The importance of sequence data from relatively little-studed phylogenetic lines is stressed. A procedure is illustrated which circumvents the computational difficulty of evaluating the astronomically large number of possible trees, without resorting to suboptimal methods.
摘要
最小突变树和几乎最小的树是根据两个数据集构建的，一个是来自多种生物的苯丙氨酸tRNA序列数据集，另一个是5S RNA序列数据集。两组结果相互一致。使用总加权突变距离标准比较代表先前进化假说的树。强调了来自研究较少的系统发育谱系的序列数据的重要性。阐述了一种程序，该程序无需采用次优方法就能规避评估数量庞大得惊人的可能树的计算难题。
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