Levy G G, Mailland M L
J Periodontol. 1980 Jul;51(7):393-9. doi: 10.1902/jop.1980.51.7.393.
A histologic study was done to observe the influence of occlusal hypofunction on periodontal tissues and the physiologic drift process, and to elucidate the origin of periodontal ligament narrowing. Twenty-four Wistar rats were used. Hypofunction was induced by extracting the right maxillary molars. Histologic observations were reported on the right lower jaws which were fixed, decalcified, sectioned and stained according to classical histologic methods. Two groups of five animals each were used for a complementary study study using sequential fluorescent labeling in order to evaluate the bone formation rate. After 15 days of hypofunction, the periodontal ligament was obviously narrowed and its structure was disorganized. Woven-bone formation was noted at the top of the interradicular septa, at the bottom of the sockets and along their modeling sides. At 30 days and at intervals up to 3 months, the periodontal ligament remained disorganized and narrowed. The newly-formed bone was engaged in a maturation process. Nevertheless, osteoporosis was also observed at the inferior part of the interradicular septa. Fluorescent labeling confirmed the histologic findings and showed that the induced bone formation is related to periodontal ligament narrowing and the supra-eruption process.
进行了一项组织学研究，以观察咬合功能减退对牙周组织和生理性牙移位过程的影响，并阐明牙周膜变窄的原因。使用了24只Wistar大鼠。通过拔除右上颌磨牙诱导功能减退。对右下颌骨进行组织学观察，按照经典组织学方法进行固定、脱钙、切片和染色。另外两组各五只动物用于补充研究，采用连续荧光标记法以评估骨形成率。功能减退15天后，牙周膜明显变窄，结构紊乱。在根间间隔顶部、牙槽窝底部及其塑形面可见编织骨形成。在30天及直至3个月的间隔时间内，牙周膜仍紊乱且变窄。新形成的骨进入成熟过程。然而，在根间间隔下部也观察到骨质疏松。荧光标记证实了组织学结果，并表明诱导的骨形成与牙周膜变窄和牙齿过度萌出过程有关。
