临床使用的染料对大鼠和人肺中前列腺素失活的抑制作用。
Inhibition by clinically used dyes of prostaglandin inactivation in rat and human lung.
作者信息
Bakhle Y S
出版信息
Br J Pharmacol. 1981 Apr;72(4):715-21. doi: 10.1111/j.1476-5381.1981.tb09153.x.
Abstract
- The effect of several clinically used dyes on prostaglandin E2 (PGE2) inactivation was studied in rat and human isolated lung. 2. All the dyes, given as infusions through the pulmonary circulation, inhibited the inactivation of PGE2 as measured by bioassay. The action of the dyes was readily reversible on stopping the infusion. 3. The concentration producing 30% inhibition varied from 0.6 microM for indocyanine green to over 100 micro M for methylene blue. 4. Inhibition of PGE2 inactivation was also observed when the dyes were given as bolus injections during PGE2 infusions through the lung. 5. These dyes are therefore not physiologically inert as they had previously been thought to be and their interaction with prostaglandins may affect the variables they are used to measure.
摘要
- 在大鼠和人类离体肺中研究了几种临床使用的染料对前列腺素E2（PGE2）失活的影响。2. 所有染料通过肺循环输注时，通过生物测定法测量发现其抑制了PGE2的失活。停止输注后，染料的作用很容易逆转。3. 产生30%抑制作用的浓度范围从吲哚菁绿的0.6微摩尔/升到亚甲蓝的超过100微摩尔/升。4. 在通过肺输注PGE2期间进行推注给药时，也观察到染料对PGE2失活的抑制作用。5. 因此，这些染料并非如之前所认为的那样在生理上无活性，它们与前列腺素的相互作用可能会影响它们用于测量的变量。
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本文引用的文献
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Selective passage of prostaglandins across the lung.前列腺素在肺中的选择性转运。
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