Garrard G S, Littler W A, Redman C W
Thorax. 1978 Aug;33(4):488-92. doi: 10.1136/thx.33.4.488.
Serial lung function studies were performed in ten healthy, primiparous women aged 21--28. Measurements were made at two-monthly intervals during pregnancy and included functional residual capacity (FRC), total lung capacity (TLC), vital capacity (VC), specific conductance (SGaw) and closing volume (CV) on each occasion. Closing volume expressed as formular: (see text), showed a progressive rise during pregnancy in all subjects with a linear relationship to time (P less than 0.001, P greater than 0.01, respectively). No consistent changes in lung volume could be shown during pregnancy over the study period. It is suggested that the increase in closing volume during pregnancy might result in abnormalities of distribution of ventilation sufficient to explain the maternal blood gas disturbances of pregnancy.
对10名年龄在21至28岁之间的健康初产妇进行了系列肺功能研究。在孕期每隔两个月进行测量，每次测量包括功能残气量（FRC）、肺总量（TLC）、肺活量（VC）、比传导率（SGaw）和闭合气量（CV）。闭合气量以公式表示：（见正文），在所有受试者孕期均呈逐渐上升趋势，与时间呈线性关系（分别为P<0.001，P>0.01）。在研究期间，孕期肺容量未显示出一致的变化。提示孕期闭合气量增加可能导致通气分布异常，足以解释孕期母体血气紊乱。
