Murata M, Kuno K, Fukami A, Sakamoto G
J Natl Cancer Inst. 1982 Dec;69(6):1229-34.
The physical and reproductive traits known to be risk factors for breast cancer were correlated with familial predisposition for this disease by the use of hospital records of 3,867 patients with breast cancer, of whom 186 had one or more relatives with breast cancer and were called "familial patients." Various characteristics in the total series of patients were compared with familial patients matched for year of birth. The mean age at menarche was significantly less in familial compared with the total series of patients, especially for premenopausal patients; however, no difference was observed in the mean age at marriage between the two groups. Familial patients were slightly taller as compared to the total series of patients, but no difference was detected in body weight between the two groups. Because age at menarche and the stature are highly correlated, they may be influenced by an underlying common hormone effect that may influence the familial nature of breast cancer.
通过查阅3867例乳腺癌患者的医院记录，将已知的乳腺癌风险因素（身体特征和生殖特征）与该疾病的家族易感性进行关联分析。其中186例患者有一个或多个患乳腺癌的亲属，被称为“家族性患者”。将所有患者的各种特征与按出生年份匹配的家族性患者进行比较。家族性患者的月经初潮平均年龄明显低于所有患者，尤其是绝经前患者；然而，两组之间的平均结婚年龄没有差异。与所有患者相比，家族性患者略高，但两组之间的体重没有差异。由于月经初潮年龄和身高高度相关，它们可能受潜在的共同激素效应影响，而这种效应可能影响乳腺癌的家族特性。
