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Proc Natl Acad Sci U S A. 1982 Oct;79(20):6342-6. doi: 10.1073/pnas.79.20.6342.
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本文引用的文献

1
Primary structural: analysis of the transplantation antigens of the murine H-2 major histocompatibility complex.主要结构：小鼠H-2主要组织相容性复合体移植抗原的分析
Annu Rev Biochem. 1981;50:1025-52. doi: 10.1146/annurev.bi.50.070181.005113.
2
Isolation of a cDNA clone for the murine transplantation antigen H-2Kb.小鼠移植抗原H-2Kb的cDNA克隆的分离
Proc Natl Acad Sci U S A. 1982 May;79(10):3270-4. doi: 10.1073/pnas.79.10.3270.
3
The 48-base-long primordial building block of immunoglobulin light-chain variable regions is complementary to the primordial building block of heavy-chain variable regions.免疫球蛋白轻链可变区48个碱基长的原始构建块与重链可变区的原始构建块互补。
Proc Natl Acad Sci U S A. 1982 Apr;79(7):2338-41. doi: 10.1073/pnas.79.7.2338.
4
Identification of the 48-base-long primordial building block sequence of mouse immunoglobulin variable region genes.小鼠免疫球蛋白可变区基因48个碱基长的原始构建模块序列的鉴定。
Proc Natl Acad Sci U S A. 1982 Mar;79(6):1999-2002. doi: 10.1073/pnas.79.6.1999.
5
Mouse immunoglobulin coding sequences for the heavy-chain variable region arose as repeats of the two short building blocks.小鼠重链可变区的免疫球蛋白编码序列是由两个短构建模块重复产生的。
Proc Natl Acad Sci U S A. 1982 Jan;79(1):132-6. doi: 10.1073/pnas.79.1.132.
6
Three cDNA clones encoding mouse transplantation antigens: homology to immunoglobulin genes.三个编码小鼠移植抗原的cDNA克隆：与免疫球蛋白基因的同源性
Cell. 1981 Apr;24(1):125-34. doi: 10.1016/0092-8674(81)90508-0.
7
Exon/intron organization and complete nucleotide sequence of an HLA gene.一个HLA基因的外显子/内含子结构及完整核苷酸序列
Proc Natl Acad Sci U S A. 1982 Feb;79(3):893-7. doi: 10.1073/pnas.79.3.893.
8
Complete nucleotide sequence of mouse immunoglobulin mu gene and comparison with other immunoglobulin heavy chain genes.小鼠免疫球蛋白μ基因的完整核苷酸序列及其与其他免疫球蛋白重链基因的比较。
Nucleic Acids Res. 1980 Sep 11;8(17):3933-45. doi: 10.1093/nar/8.17.3933.
9
Recognition of conformational determinants on H-2 by cytolytic T lymphocytes.细胞毒性T淋巴细胞对H-2上构象决定簇的识别。
Nature. 1982 Jun 10;297(5866):511-3. doi: 10.1038/297511a0.
10
Original domain for the serum albumin family arose from repeated sequences.血清白蛋白家族的原始结构域源自重复序列。
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7657-61. doi: 10.1073/pnas.78.12.7657.

鉴定整个I类主要组织相容性复合体抗原基因的45个碱基长的原始构建模块。

Identification of the 45-base-long primordial building block of the entire class I major histocompatibility complex antigen gene.

作者信息

Ohno S, Matsunaga T, Epplen J T, Itakura K, Wallace R B

出版信息

Proc Natl Acad Sci U S A. 1982 Oct;79(20):6342-6. doi: 10.1073/pnas.79.20.6342.

DOI:10.1073/pnas.79.20.6342
PMID:6959121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC347117/
Abstract

Within the 885-base-long incomplete coding sequence for the mouse class I major histocompatibility complex (MHC) antigen H-2Kb heavy chain, we have identified 32 recurring base oligomers (1 decamer, 4 octamers, 9 heptamers, and 18 hexamers), the decamer being T-C-A-C-C-C-T-G-A-G. The compilation of these recurring base oligomers led to the identification of the 45-base-long primordial building block for this class of genes which is: C-C-T-G-C-G-G-A-C-A-A-T-G-T-C-A-C-C-C-T-G-A-G-C-T-G-C-T-G-G-G-C-T-C-T-G-G-G-C-G - T-T-G-A-C. Inasmuch as these base oligomers that recurred within the mouse H-2Kb coding sequence proper also recurred within the adjacent, transcribed noncoding sequence, we conclude that the entire approximately equal to 4,000-base-long germ-line DNA segment containing eight or nine separate exons of the coding sequence for class I MHC antigen heavy chains can be construed as having evolved from tandem repeats of this one 45-base-long primordial building block.

摘要

在小鼠I类主要组织相容性复合体（MHC）抗原H-2Kb重链的885个碱基长的不完整编码序列中，我们鉴定出32个重复出现的碱基寡聚物（1个十聚体、4个八聚体、9个七聚体和18个六聚体），该十聚体为T-C-A-C-C-C-T-G-A-G。这些重复出现的碱基寡聚物的汇编导致鉴定出这类基因的45个碱基长的原始构建模块，即：C-C-T-G-C-G-G-A-C-A-A-T-G-T-C-A-C-C-C-T-G-A-G-C-T-G-C-T-G-G-G-C-T-C-T-G-G-G-C-G - T-T-G-A-C。由于这些在小鼠H-2Kb编码序列本身中重复出现的碱基寡聚物也在相邻的转录非编码序列中重复出现，我们得出结论，包含I类MHC抗原重链编码序列的大约4000个碱基长的种系DNA片段，其八个或九个单独的外显子，可以被解释为是由这个45个碱基长的原始构建模块的串联重复进化而来的。