Iashchenko L V, Birkun A A, Karpitskiĭ V V, Eremenko A E
Zh Mikrobiol Epidemiol Immunobiol. 1978 Apr(4):88-92.
It was shown that in the immunization of rabbits with sorbed staphylococcus toxoid and human albumin, at the height of the immune response there occurred an intensification of biosynthesis and destabilization of lysosomal membranes of blood leukocytes, with a simultaneous development of microcirculation disturbances in the lungs. Development of pneumonia against the background of immunization led to a greater destabilization of the lysosomic membranes of leukocytes and to the intensification in the lungs of infiltrative and destructive processes, in comparison with the course of inflammation in the nonimmunized animals. Peculiarities of the antigens used caused some specificity in the course of pneumonia. A relationship between the changes of blood leukocytes and disturbances in the lungs in immunization is supposed.
结果表明，在用吸附葡萄球菌类毒素和人白蛋白对家兔进行免疫时，在免疫反应高峰期，血液白细胞的生物合成增强，溶酶体膜不稳定，同时肺部出现微循环障碍。与未免疫动物的炎症过程相比，免疫背景下肺炎的发展导致白细胞溶酶体膜更不稳定，肺部浸润和破坏过程加剧。所用抗原的特性导致肺炎过程具有一定特异性。推测免疫过程中血液白细胞变化与肺部障碍之间存在关联。
