Kam-Hansen S, Roström B, Link H
Acta Neurol Scand. 1980 May;61(5):298-305. doi: 10.1111/j.1600-0404.1980.tb01496.x.
The active T cell rosette test--that is determination of T lymphocytes with high affinity for sheep erythrocytes after incubation at 37 degrees C for 1 h--defines a T cell subset that has been claimed to parallel cell-mediated immunocompetence in e.g. viral diseases. In 16 patients who have had acute unilateral idiopathic optic neuritis (ON), lower percentages of active T cells were found in CSF compared to blood, irrespective if the interval between the first bout of ON and the present study was 2 months or 26 years, and irrespective of degree of mononuclear pleocytosis or humoral immune variables in CSF. The same distribution of active T cells has previously been observed in multiple slcerosis (MS). The percentages of active T cells in peripheral blood from the patients with ON were normal. Determination of active T cell does not seem to discriminate those patients with ON who are likely to develop MS. One explanation could be that ON and MS have an etiologic agent in common but that a part of patients with ON have an until now undefined competence to limit the demyelinating process.
活性T细胞玫瑰花结试验（即在37℃孵育1小时后测定对绵羊红细胞具有高亲和力的T淋巴细胞）可确定一个T细胞亚群，据称该亚群在例如病毒性疾病中与细胞介导的免疫能力平行。在16例急性单侧特发性视神经炎（ON）患者中，无论首次发作ON与本研究之间的间隔是2个月还是26年，也无论脑脊液中单核细胞增多程度或体液免疫变量如何，脑脊液中活性T细胞的百分比均低于血液中的百分比。此前在多发性硬化症（MS）中也观察到了活性T细胞的相同分布。ON患者外周血中活性T细胞的百分比正常。活性T细胞的测定似乎无法区分哪些ON患者可能会发展为MS。一种解释可能是ON和MS有共同的病原体，但一部分ON患者具有迄今未明确的限制脱髓鞘过程的能力。
