Cherchi M, Catovsky D
Clin Exp Immunol. 1980 Feb;39(2):411-5.
Mouse RBC (M) rosettes were investigated on lymphocytes from peripheral blood (PB) and various tissues in twenty patients with chronic lymphocytic leukaemia and one with follicular lymphoma. In all cases studied, the percentage of M rosettes was significantly higher in PB (median 64%) than in bone marrow (median 15%) and lymph node (median 12%). These differences were statistically significant (P less than 0.01). The possibility that these differences were related to technical factors was ruled out by a number of control procedures. It is suggested that the different expression of M rosette formation reflects the property which determines whether a lymphocyte enters the peripheral blood or remains fixed in the tissues.
对20例慢性淋巴细胞白血病患者和1例滤泡性淋巴瘤患者外周血(PB)及各种组织中的淋巴细胞进行了小鼠红细胞(M)花环试验。在所有研究病例中,PB中M花环的百分比(中位数64%)显著高于骨髓(中位数15%)和淋巴结(中位数12%)。这些差异具有统计学意义(P<0.01)。一系列对照程序排除了这些差异与技术因素有关的可能性。提示M花环形成的不同表达反映了决定淋巴细胞进入外周血还是固定在组织中的特性。